ID A0A663DZI1_AQUCH Unreviewed; 1024 AA.
AC A0A663DZI1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Insulin degrading enzyme {ECO:0000313|Ensembl:ENSACCP00020005139.1};
GN Name=IDE {ECO:0000313|Ensembl:ENSACCP00020005139.1};
OS Aquila chrysaetos chrysaetos.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Aquila.
OX NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020005139.1, ECO:0000313|Proteomes:UP000472275};
RN [1] {ECO:0000313|Ensembl:ENSACCP00020005139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR AlphaFoldDB; A0A663DZI1; -.
DR Ensembl; ENSACCT00020005356.1; ENSACCP00020005139.1; ENSACCG00020003512.1.
DR GeneTree; ENSGT00940000155780; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000472275; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000472275};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 80..216
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 243..421
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 427..707
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 711..894
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1024 AA; 118701 MW; F5B9F812FD549663 CRC64;
MRQRLLPVLR RALLRSARPW AVPASRFFPQ CRRRSFPGFQ KETNNKMNNP AIKRITNEII
KSPEDKREYR GLELANGIKA LLISDPTTDK SSAALDVHIG SLSDPPNIAG LSHFCEHMLF
LGTKKYPKEN EYSQFLSEHA GSSNAFTSGE HTNYYFDVSH EHLEGALDRF AQFFLCPLFD
ESCKDREVNA VDSEHEKNLM NDAWRLFQLE KATGNPNHPF SKFGTGNKLT LETRPTKEGI
DVRQELLKFH STYYSSNLMA ICVLGRESLD ELTCLVVKLF SEVENKNVPI PEFPEHPFQE
EHLRQLYKVV PIKDIRNLYV TFPIPDLQKY YKSNPGHYLG HLIGHEGPGS LLSELKAKGW
VNTLVGGQKE GARGFMFFII NVDLTEEGLL HVEDIILHMF QYIQKLRTEG PQEWVFQECK
DLNAVAFRFK DKERPRGYTS KLGGMLHYYP IEEVLAAEYL LEEFRPDLIE MVLDKLRPEN
VRVAIVSKSF EGKTDRTEDW YGTQYKQEAI SDEVIKKWQN ADLNGKFKLP MKNEFIPTNF
EILPLEKDAT QYPALVKDTA MSKLWFKQDD KFFLPKACLN FEFFSRYIYA DPLHCNMTYL
FIRLLKDDLK EYTYAARLSG LIYGIASGMN AILLSVKGYN DKQHILLKKI IEKMATFEID
EKRFEIIKEA YMRSLNNFRA EQPHQHAMYY LRLLMTEVAW TKDELKEALD DVTLPRLKAF
IAQLLSRLHI EALLHGNITK QAALGIMQMV EDTLIEHAHT KPLLPSQLVR YREVQLPDRG
WFVYQQRNEV HNNCGIEIYY QTDMQSTSEN MFLELFCQII SEPCFNTLRT KEQLGYIVFS
GPRRANGIQG LRFIIQSEKP PHYLESRVEA FLKTMEKCIE DMTEEAFQKH IQALAIRRLD
KPKKLSAECA KYWGEIISQQ YNFDRDNIEV AYLKTLTKDD IIQFYKVLLA IDAPRRHKVS
VHVLAREMDS CPVVGEFPCQ NDVNLAPAPP LPQPSVIENM TEFKRSLPLF PLVKPHINFM
AAKL
//
