ID   A0A663E2V1_AQUCH        Unreviewed;      1736 AA.
AC   A0A663E2V1;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=5'-3' exoribonuclease 1 {ECO:0000313|Ensembl:ENSACCP00020006567.1};
GN   Name=XRN1 {ECO:0000313|Ensembl:ENSACCP00020006567.1};
OS   Aquila chrysaetos chrysaetos.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC   Accipitrinae; Aquila.
OX   NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020006567.1, ECO:0000313|Proteomes:UP000472275};
RN   [1] {ECO:0000313|Ensembl:ENSACCP00020006567.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSACCT00020006866.1; ENSACCP00020006567.1; ENSACCG00020004482.1.
DR   GeneTree; ENSGT00670000098080; -.
DR   Proteomes; UP000472275; Unplaced.
DR   GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 2.170.260.40; -; 1.
DR   Gene3D; 2.30.30.750; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR016494; 5_3_exoribonuclease_1.
DR   InterPro; IPR041385; SH3_12.
DR   InterPro; IPR040992; XRN1_D1.
DR   InterPro; IPR047007; XRN1_D1_sf.
DR   InterPro; IPR041106; XRN1_D2_D3.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR047008; XRN1_SH3_sf.
DR   PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF18129; SH3_12; 1.
DR   Pfam; PF18332; XRN1_D1; 1.
DR   Pfam; PF18334; XRN1_D2_D3; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
PE   4: Predicted;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472275}.
FT   DOMAIN          1..227
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          273..608
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   DOMAIN          654..842
FT                   /note="5'-3' exoribonuclease 1 D1"
FT                   /evidence="ECO:0000259|Pfam:PF18332"
FT   DOMAIN          848..1073
FT                   /note="Exoribonuclease Xrn1 D2/D3"
FT                   /evidence="ECO:0000259|Pfam:PF18334"
FT   DOMAIN          1100..1169
FT                   /note="5'-3' exoribonuclease 1 SH3-like"
FT                   /evidence="ECO:0000259|Pfam:PF18129"
FT   REGION          1280..1317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1655..1736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1290..1309
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1655..1722
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1736 AA;  197436 MW;  41277A8274A42102 CRC64;
     MGVPKFYRWI SERYPCLSQV LKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISEDKI
     FADIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKALEKGE
     TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTVYLSG HETPGEGEHK
     IMEFIRSEKA KPHHDPNTRH CLYGLDADLI MLGLTSHEAH FALLREEVRF GGKKSQRACA
     PEETTFHLLH LSLMREYIDY EFSPVKDKIS FEYDIERIID DWILMGFLVG NDFIPHLPHL
     HINHDALPLL YRTYMAILPE LGGYINENGH LNLKRFEKYL TRLSDFDREH FSEVFVDLKW
     FESKVGNKYL NEAAGIAAEE ARKNKQKKQK AQENSMCLAA LEKNEGEVTP KTVLEDEPED
     DDLFETEFRQ YKRTYYMTKM GVEVVSDDFL ADQAECYVQA IQWILHYYYH GVQSWSWYYP
     YHYAPYLSDI HNISELKIKF ELGKPFMPFE QLLAVLPAAS KDLLPKCYQH LMISQDSPII
     EYYPPDFKTD LNGKQQEWEA VVLIPFIDEK RLLQAMESCN KYLKEEEKRR NTHSACLMYW
     YDKDAEFQYM SPWPEKFPAV ERCHTRYKTI PLDAWHVEIT HNKITKINKS ALYFCGFPTL
     KHIKHKFYLR KSGVQVFQQS SHGENMMLEI IADENSKEQM VENVASSVLG KRVFVNWPHL
     EEARVVAVSD GETKFYLEEP HGTQKLYMGN AVPPTKVAYV GDKEQSMWLK EVQGISEHYQ
     RRKGIIIHET SIVVYAQLLT GNRYQLNQNG EVYLEKQWSK QALPFVYQTV VKDIKAFDCR
     FSNIRTLDDL FPPGSTAFML GSPYYGCMGE VQDSRDVITE GRIRVVFNIP CEPQLDPLIQ
     NQHKYSVKYN PAYILASRLG VSGYLVSRFT GSIFIGRGSK KNPHGDHKAN VGLNLKFNKK
     NEEVPGYTKK VGNEWMYSSA VEQLLAEYLE RVPELFNYIA KNSQEDIFYE DDIWPGEDEN
     GAEKVQEIVA WLKAHPVSAL SRSSCDLQIL DAAIVEKIEE EIEKCKQRKS NKKVRVTVKP
     HLLYRPLEQQ NGVVPDRDAE YRLFDRVVNV RENFSVPVGL RGTIIGIKGA SRETDVLFEV
     LFDEEFLGGL TIRCSPARGY RLPSSALINL SHGSRSEMGN QKLMAIVKPQ PAVNNYNSYA
     SDLSSVCPQK VHLGGLNHSP RSLFVPTQAQ SKQGDEFCSI WQSLQNSGKS HHIQQNMHEK
     GAVLPQEIKL GTGNQFYKPG FNDSSFKGQQ RKQEPYKKFK EDSKVTRGES QPHNKISNKQ
     NFAGVNKYNV KLLKRNESPN MPVVQKAAVD GTSTGGKDNE LEGLLASLKI SKENEVQTYS
     KEARATNEEH LSPQSFAMKG TQMLKEILKI DGSDLETRNE VKSQVNDVPA PPSRQDCHGA
     ALQYRQTKRM AAYMNKPHST GGPQNTAALE TGGHPFTCPQ PALSTVSELS RICSLVGMSQ
     PDFSFLKTPQ TMTVCHIKLS NGLLVHGPQC HSEAEAKEKA ALFALQRLSS IGVNFPLPPP
     PPPPVFPNYQ PLGVPVPPGS IPPVFAQPPA NIMPPSSHMF GPVSWGTPVP KHYYPGSYPG
     NVSLAGTIPV GSHNQFIPLQ VTKKRAASKK NFELKEFQSS PQAAPLKNEQ PVSSDHIQQD
     SSSASLKSPQ AAQSTVSFQD NVATPSVPHN KSTPNTSSKR KPRKLAVNFG APKSSE
//