ID A0A663FK80_AQUCH Unreviewed; 1203 AA.
AC A0A663FK80;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=MCF.2 cell line derived transforming sequence like {ECO:0000313|Ensembl:ENSACCP00020024112.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSACCP00020024112.1};
OS Aquila chrysaetos chrysaetos.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Accipitriformes; Accipitridae;
OC Accipitrinae; Aquila.
OX NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020024112.1, ECO:0000313|Proteomes:UP000472275};
RN [1] {ECO:0000313|Ensembl:ENSACCP00020024112.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A663FK80; -.
DR Ensembl; ENSACCT00020025184.1; ENSACCP00020024112.1; ENSACCG00020016512.1.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000472275; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472275};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 22..194
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 601..781
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 793..915
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1100..1161
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1006..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 135862 MW; B7CCDE671BEF2197 CRC64;
MRCWLKIEEM ALEELMQRLN AVSQCADEIM HQDIIPLYAA DIQDQLKKQF AYLSGGRGGD
GCPVITFPDY PAFSEIPEKE FQNVLTYLTS IPSLRDAGIG FILVIDRRQD KWTSVKASIL
RIAASFPGNL QLVLVLRPTG FFHRALSDIA FKFNKDEFKM KVPIIMLGSV SELQGYIDKT
QLTEDLGGTL DYCHNRWLSR RTAIEGFAQK VKQTAQILQS FGTELAETEL PNDVQSTSSL
LATHTEKKDK MKEDIRLAVE QGDDILGSIT KPVTENPEYK LNQDQLDNQT TVERLLAQLH
ETETAFDEFW IKHQQKLEQC LRLRNFEQNF REVKAALDIV SERLSTFTDV GNSCSHVEHI
LKDLANFEEK SCETVAKARM LASEGDAFIQ SNHYAVDSII PKCSELHHLC DAFTTETERR
RNLLNKSLEL HGLLEKSLKW CDEGIYLLAS QPVDKCQSQD GAESALQEIE KFLDTGAGNK
IKELNKIYRE YAHILNEDLK EHVQKVFQKQ ESMEEMFQKR QVSLKKLAAK QTRPVQPVAP
RPEAFVKSPC TSPGLQREYV SNSESSALRR VNCRRGKSEM TELHQSRGGS TMDDEENLAV
LRQHVMNELI ETERAYVEEL LCVLEGYAAE MDNPLMAHLI SPELQNKKDI LFGNMEEIYH
FHNRIFLREL ENYVEFPELV GRCFLDQMED FQIYEKYCQN KPRSESLWRQ FSDSVFFQEC
QRKLDHKLSL DSYLLKPVQR ITKYQLLLKE MLKYSKNCEG AEDLQEALTS ILGILKAVND
SMHQIAITGY DGNLNELGKL LMQGSFNVWT DHKKGHSKVK DLARFKPMQR HLFLHEKAVL
FCKKREENGE GYEKAPSYSY KHSLNMAAVG ITENVKGDAK KFEIWYNARE EVYIIQAPTP
EVKATWVNEI RKVLTSQLQA CREASQHRTL EQTQSLPLPA SSCASPSRNH IRNTKKMEER
KADLASLEGY GTAVAPKYPE KGKDDTSSTS ECSVLSKKRF TLQGFTNLKS QKETPSPSAK
SQTLPMILLT GPASPTSPDK KAKRHEVVSD PTPFGLRGWA KTSHSLDASE ENDGWSSAED
PLNSSDAEEE GGGGGGEMKL TPGKYTVVTD YEKGVSEEFT VKSGELVQLI REGEDGLWYV
KNLSTGKEGW IPANNLLMLI GNSKSAQSLS SSESGTASST LSTSSSCSDS CNASSTSFSD
IKG
//
