ID A0A665T035_ECHNA Unreviewed; 566 AA.
AC A0A665T035;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
GN Name=parn {ECO:0000313|Ensembl:ENSENLP00000002674.1};
OS Echeneis naucrates (Live sharksucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Echeneidae; Echeneis.
OX NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000002674.1, ECO:0000313|Proteomes:UP000472264};
RN [1] {ECO:0000313|Ensembl:ENSENLP00000002674.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR AlphaFoldDB; A0A665T035; -.
DR Ensembl; ENSENLT00000002855.1; ENSENLP00000002674.1; ENSENLG00000001311.1.
DR Proteomes; UP000472264; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT DOMAIN 179..245
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 141..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 64898 MW; AEDC227BF9B63DC8 CRC64;
MEVTRKNYKD SLNTVYSAIE EADFLAIDGE FSGISDGPNV SALTNGLDTP EERYTKLKKH
SMDFLLFQFG LCTFKYDQAK SKYITKPFNF YIFPKPFNRT SPDIKFICQS SSIDFLASQG
FDFNKVFCHG IPYLNQDEEA QLREQTEERR NQHANGGGTP SYISPSSSKS PANVPEEHKD
FINRVIEKVE ALFSNSEKTL DLEPCTGFQR KLIYQTLNWK FPKGLHVETV ETEKKERYIQ
VIKVDEEERK RREQQKLERE QEELNDAVGF SRVIHAISKS GKLVVGHNML LDVMHTIHQF
YCSLPEDLQD FKEVTMCVFP RLLDTKLMAS TQPFKELITN TSLAELEKQL KDTPFKSPQV
ETAAGFPSYD TAQEQLHEAG YDAYITGLCF ISMANYLGSF LTPPKAYISA RSKLIEPFFN
KLFLMRIIDI PYLNITGPDL QPKRDHVLYV TFPKEWKTSD LYQLFSAFGN IQVSWVDDTS
AFVSLSQTDQ VQIAMNTSRY AESYRIQTYA EYVQGKQLEK EKLGQTVKSW GEDGWVKSHY
ASSTTSSGFG FYLWPPVPGQ IECIVD
//
