ID A0A665TBW8_ECHNA Unreviewed; 1012 AA.
AC A0A665TBW8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSENLP00000000186.1};
OS Echeneis naucrates (Live sharksucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Echeneidae; Echeneis.
OX NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000000186.1, ECO:0000313|Proteomes:UP000472264};
RN [1] {ECO:0000313|Ensembl:ENSENLP00000000186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A665TBW8; -.
DR Ensembl; ENSENLT00000000199.1; ENSENLP00000000186.1; ENSENLG00000000077.1.
DR Proteomes; UP000472264; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472264};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 120..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..85
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 119..605
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 614..1012
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 111595 MW; 5FC026F933F00866 CRC64;
MERFKSNGGE HVNNAYDPTL DDPFYEASFP NGENRTVRPS VVSAFGHDTL DRVPHIDFYR
NAGSVSGHRA VRPSLQELHD VFQKVNDGET SDGTPSDDLE SAAPVDKSQG GVKFGWIRGV
LVRCMLNIWG VMLFIRLSWV FGQAGWGLGI VVILLSCVVT VITGLSMSAI CTNGVVRGGG
AYYLISRSLG PEFGGSIGLI FAFANAVAVA MYVVGFAETV VDLLKQKRVA ACSSVYVPRP
LSVLQIILLI ILLVAIVNVF VGTFIPATND KKAKGFFNYN TKIFLENFAP DFRKGESFFS
VFAIFFPAAT GILAGANISG DLRDAQKAIP KGTLLAILIT GVTYLAVALC VSATVLRDAT
GNLNDTVALG TLCDGSSAIA CELGYNFSSC AVEKCNFGLM NNFQVMTMVS GFGPLIIAGT
FSATLSSALA SLVSAPKVFQ ALCKDNIYKA LHFFAKGHGK NNEPIRGYVL TFVISVAFIL
IGDLNAIAPI ISNFFLASYA LINFSCFHAS YAKSPGWRPG YKYYNMWLSL FGALLCCVVM
FVINWWAALL TYAIEFLLYI YVTVKKPNVN WGSSTQAVTF VSAVSNALSL TAVEDHVKNF
RPQILALTGS ARSRPALLDL AHSFSKTYGL CLTCEVFVGP RSEALQEMNA SMEKNQQWLR
KTKRKAFYAA VACDKFREGT DSLLQASGLG RLKPNTLMMG FKKDWRTAGT ESVQSYVGIL
HDAFDYEYGT VILRMNQGLD VSHFVEAEDE MLKAAKEQQV LENEITPSGG KSRGLFRKSR
NSSQQVLTTR VSVCGPPPEH VAKMNERLLE ASAQFKKKQP KGTIDVWWLF DDGGLTLLLP
YILTTRKKWK NSKLRIFIAG LPGRGELDKM EMKSLLKKFR IDCTDITVID DIHLRPTSDS
LQELEEMIEP FRLHEGVKDT AEAEALKGEW SWKITDEELN TFEEKTHLQV RLNELLQKNS
KSANLIIVSM PIARKESVSD YLYMAWLDIL TKDLPPTLLI RGNHKSVLTF YS
//
