ID A0A665TRM8_ECHNA Unreviewed; 684 AA.
AC A0A665TRM8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 4 {ECO:0000313|Ensembl:ENSENLP00000006151.1};
GN Name=hsd17b4 {ECO:0000313|Ensembl:ENSENLP00000006151.1};
OS Echeneis naucrates (Live sharksucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Echeneidae; Echeneis.
OX NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000006151.1, ECO:0000313|Proteomes:UP000472264};
RN [1] {ECO:0000313|Ensembl:ENSENLP00000006151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A665TRM8; -.
DR Ensembl; ENSENLT00000006433.1; ENSENLP00000006151.1; ENSENLG00000002884.1.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000472264; Unplaced.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT DOMAIN 440..553
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 576..679
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 684 AA; 74664 MW; 15C2AA9926F00E68 CRC64;
LVNDLGADTK GGGKSSAAAD KVVEEIKAKG GKAVANYDSV EDGEKLIQAA LDSFGRIAQT
LKLLLLFFLP RILRDRSFPR TSDLDWDLIQ RIHLRGSFLV TRAAWNHMKN QKFGRIIMTA
SAAGIYGNFG QANYSAAKLG MLGLANTLAI EGRKYNIHCN TIAPVAGSRL TETVMPPDLV
ASLKPEYVSP LVLWLCHDQC QENGGLFEVG AGWIGKLRWE RSRGRIVRQK NQPMNPEAVR
DQWDKICDFT DATKPASTGE SLQSMVSVLL QLESQETVGA NPTAASASAQ AIGQKLPPST
FNFNHIQCIL YALGVGMSTK DPDHLRFLYE GHPDFSCLPT FGVIPSQAAM MDGGLIFSIL
LCFFSLLMKL PIQFLICELT SQATIADVLD KGSGAVIILD VNTYSRGELV CFNQFSVFVV
GAGGFGGKRT SEKAKAVLPP PQRAPDAVVI DSTTRDQAAL YRLSGDWNPL HIDPSFAAMG
GFQAPILHGL CSFGFAARHV LKQFAANDPS RFKSIKVRFV KPVLPGQSLQ TEMWKEGNRI
HIQSKVKETD AVVLSGAYID LHATSEGGGL QSELVFEEIR RRIKDLGSEL VKKVNAVFSW
EITKDGKNAA QWTIDLKNGG GALHKGPYPG KADLTFTVSD ENFVQMVQGK LNPQKAFFSG
KLKARGNIML SQKLEVILKD YAKL
//
