ID   A0A665VJD2_ECHNA        Unreviewed;       472 AA.
AC   A0A665VJD2;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE            EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE   AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
OS   Echeneis naucrates (Live sharksucker).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Echeneidae; Echeneis.
OX   NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000031796.1, ECO:0000313|Proteomes:UP000472264};
RN   [1] {ECO:0000313|Ensembl:ENSENLP00000031796.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- SUBCELLULAR LOCATION: Melanosome membrane
CC       {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004573}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family.
CC       {ECO:0000256|ARBA:ARBA00009928}.
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DR   AlphaFoldDB; A0A665VJD2; -.
DR   Ensembl; ENSENLT00000032711.1; ENSENLP00000031796.1; ENSENLG00000014036.1.
DR   Proteomes; UP000472264; Unplaced.
DR   GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT   DOMAIN          188..205
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          357..368
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   472 AA;  54809 MW;  C436E5CB53534204 CRC64;
     MCFVFLYFAK QVELLLDYTS TSLILFLANQ EALDSRTCCP VWNGSPCGQT AGRGYCAQHF
     LEGGDLPIDY RVDWPNSFYN KVCACYGNFD GFDCGVCSPG WQGPDCLEPH RVDRKEITDM
     YEDERELFIS NLDHAKHTIS NRYKILTSND TTKAGNFKFH EATVYDLYVW LHYYAAKKYA
     DTDDDAAHRG PAFPFWHRIF LLFIEREIRL LTGNHNFFIP YWDWTRTDHC NICTNDYFGA
     VDPDGHIDQG SRFSKWKVRS PSCSFLNASF LLLLKLRKPG KDRSADTLPT SGDVRRTVCE
     DNYDTPPFNK MSKHSFRSRL EGFDIPRDSR NLQSAMHNLV HDYFNGTMSH LPTAANDPLF
     MVHHSFVDKL LEVWLERHRY ASYPESDEIH KAQRKESYMA PFFPLRTNGY YWNRSILSLG
     YKYIEHSIPH PGAVHIGEVY HQSPYCLWRE AEGTDHLKLV RAHHSCTLSN PD
//