ID   A0A665W3G8_ECHNA        Unreviewed;      1257 AA.
AC   A0A665W3G8;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=5-oxoprolinase, ATP-hydrolysing {ECO:0000313|Ensembl:ENSENLP00000038358.1};
GN   Name=oplah {ECO:0000313|Ensembl:ENSENLP00000038358.1};
OS   Echeneis naucrates (Live sharksucker).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Echeneidae; Echeneis.
OX   NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000038358.1, ECO:0000313|Proteomes:UP000472264};
RN   [1] {ECO:0000313|Ensembl:ENSENLP00000038358.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   AlphaFoldDB; A0A665W3G8; -.
DR   Ensembl; ENSENLT00000039377.1; ENSENLP00000038358.1; ENSENLG00000016529.1.
DR   Proteomes; UP000472264; Unplaced.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT   DOMAIN          10..216
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          236..532
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          544..713
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          737..806
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   DOMAIN          806..1223
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1257 AA;  136776 MW;  C539376C124EAF41 CRC64;
     MAETEGKFDF AIDRGGTFTD VFARLPDGRE RVLKLLSRDP QNYKDAPTEG IRRVLEEETG
     QPFPREQPVE TSLIGWIRMG TTVATNALLE REGERTALLV TKGFKDLLHI GTQARPKLFD
     LEVSVPDVLY EEVIEVDERI ILRQDGCQLP RKDPKRIVTG STGDSLEVWK ELDLAQVEKD
     LRGVLSRGIT SLAVLLLHSY TWSDHEKAVG ALARSLGFTQ VSLSSEVMPM VRAVPRGYTV
     CADAYLTPKI HQYLKGFTSG FKGGLKDVDV LFMQSDGGLT PMEHFCGSRA ILSGPAGGVV
     GYAITSYSQM ENKPVIGFDM GGTSTDVSRY AGHYEHVFEA STAGVTLQAP QLDINTVAAG
     GGSRLFFRSG MFVVGPESAG AHPGPACYRK GGPLTVTDAN LALGRLLPSF FPKIFGPGEN
     EPLSMEETMK HFNYLTEEIN LFLSPSQSKM SVEEVAMGFI RVANEAMCRP IRALTQAKGH
     DTSQHVLACF GGAGGQHACA IARALGMKTV FIHKYSGVLS AYGLALADVV EEVQEPCSLK
     YAQHCFSELD RRVEQLSKRC HDTLCARGFS SSQITTEVFL HLRYEGTDCA LMITAAGHPS
     SSQSCRAGDF HSAFTERYLK EFGFTILDRP IVVDDIRVRG CGKSGIKSVY KTKLGSHQAK
     PVTMTKCYFE DGYLDTSVYL WEELPCGHSI QGPAIIIDKN STILVEPCCE ARLTEGGDVC
     LTVGSDPHCA LGTELNTVQL SIFSHRFMSI AEQMGRVLQR TSISTNIKER LDFSCAVFGP
     DGGLVSNAPH IPVHLGAMQE TVQYQVFRKG VSGAVFFVAS RGHHADIGGI TPGSMPPHST
     SLQQEGAVFM SFKIVTRGVF QEEAVTEALM APAKYPDCSG TRNLHDNLSD LRAQVAANQR
     GSQLVGELIE SYGLDVVQAY MGYIQSNAEL AVRDMLRDFA RCRRQQTGLL EVESEDFMDD
     GTPIRLRVQI NEEQGSAVFD FTGTGTEVLG NCNAPRAITL SALIYCLRCM VGQDIPLNQG
     CLAPIKVIIP PGSILQPSQN AAVVGGNVLT SQRVVDVIFR AFEMCAASQG CMNNISFGSE
     KIGYYETVAG GAGAGPSWNG RSGVHSHMTN TRITDPEILE KRYPVILEQF SLRPGSGGKG
     KYCGGDGVIR KLLFRNKVVL SVLTERRSTC PYGLQGGEDG AAGLNLLHRA DGRLLNLGAK
     TSVSLEPGDM FCLYTPGGGG FGREDDTNSK PQKRRRLNET FLERGSVFEY RMAQEGV
//