ID   A0A665X340_ECHNA        Unreviewed;       904 AA.
AC   A0A665X340;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Ankyrin repeat and LEM domain containing 2 {ECO:0000313|Ensembl:ENSENLP00000050680.1};
GN   Name=ankle2 {ECO:0000313|Ensembl:ENSENLP00000050680.1};
OS   Echeneis naucrates (Live sharksucker).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangiformes; Echeneidae; Echeneis.
OX   NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000050680.1, ECO:0000313|Proteomes:UP000472264};
RN   [1] {ECO:0000313|Ensembl:ENSENLP00000050680.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ANKLE2 family.
CC       {ECO:0000256|ARBA:ARBA00007597}.
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DR   AlphaFoldDB; A0A665X340; -.
DR   Ensembl; ENSENLT00000051920.1; ENSENLP00000050680.1; ENSENLG00000021280.1.
DR   Proteomes; UP000472264; Unplaced.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.720.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR   InterPro; IPR003887; LEM_dom.
DR   InterPro; IPR011320; RNase_H1_N.
DR   PANTHER; PTHR12349; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR12349:SF4; ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   Pfam; PF03020; LEM; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00540; LEM; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF63451; LEM domain; 1.
DR   PROSITE; PS50954; LEM; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT   DOMAIN          43..87
FT                   /note="LEM"
FT                   /evidence="ECO:0000259|PROSITE:PS50954"
FT   REGION          119..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          720..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          768..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        735..749
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..798
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..869
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  99791 MW;  ADA88DC5E0B587AF CRC64;
     MSSRTVWFSS VSSQRRRIKF VTLQPENPPR MTYLGVTVME AVLSRLKGLS ADELREEFAR
     ADVKCGPITA TTRATFEKKL ARVLAGSEST ESANSSSTGS TAAVADHANP VPSAISAITN
     AAKSSSHPEA ASEELDFGYS QGLNPPEEEE LSVKTTSISS TESSNFQSKT ETPSKSPQVS
     PTSYYGVCPL WDDVLARNER AHVYTDKKDA LQAVKMMKGA RFKAFPNRQD AEKFAKGICD
     YCPSPNKSTP CVSPVKPCLV VSKDNMEVDT INRERANSYK SPRTQDLTAK LRKAVEKGDE
     SAFSELVLSN PRYLIGSGDN PTIVQEGCRY NVMHVAAKEN QAGIAQLLLN TLENPEFMRL
     MYPDDQEVML QKRIRYIVDL YLNTPDKAGF ETPLHFACKF GCPDVVNVLC SHPDIDKNCK
     NKDGLKPCDL ICSRKNKTQE VKQKIGDYLE DRCYIPLLRA IDNTSQPIIG APWSPESSEN
     LSLIHRHTRS PMDPLMTVTA FAGPLSPSKA DDFRRSWKTP PRDRADLFHN ILKSDPDRGA
     ERVGRDLARE MGHPWAEYWD FLDSFVDLSS NEGLRKLEEY LSGKDFSPRA HEEAGENETS
     NRFKSPSPGK PKKFCNSISV GAFLDEGDDI SLEEMKNRQN AALTSITSSA ASKDGLKGAV
     GGHEFHILLL SPGVVCKNGV CSSSRDRTHN GDKVSPRTSP SSSCLLSPVS NLMVEFERMS
     IQEPLDSPTS CRERRSSGGS RHRDVRDSYV ASSGTDLSFG LNRLSLSHNS QDGEAAEGPS
     WRAEEGGTEE RESPTKLDKE VLSAIDGIDV DPQKYPSIHK WKSTMASYSV SDMQSWPSPV
     VVKPRLRMQH QTPGSPVSGL ISPTSRFSPA RHAVSPDFSP SRYSPANASY IQRIRLKRLN
     EPPV
//