ID A0A665X518_ECHNA Unreviewed; 1045 AA.
AC A0A665X518;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSENLP00000051405.1};
GN Name=hip1r {ECO:0000313|Ensembl:ENSENLP00000051405.1};
OS Echeneis naucrates (Live sharksucker).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangiformes; Echeneidae; Echeneis.
OX NCBI_TaxID=173247 {ECO:0000313|Ensembl:ENSENLP00000051405.1, ECO:0000313|Proteomes:UP000472264};
RN [1] {ECO:0000313|Ensembl:ENSENLP00000051405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR AlphaFoldDB; A0A665X518; -.
DR Ensembl; ENSENLT00000052653.1; ENSENLP00000051405.1; ENSENLG00000020855.1.
DR Proteomes; UP000472264; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000472264}.
FT DOMAIN 738..979
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 535..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 938..974
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 535..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 117890 MW; 5BD00AFC6A85A31D CRC64;
MNSIRQVPTR VKRAPVCHTG IILGTHREKG AYTFWSYALG FPLASSSILS WKFCHVLHKV
LRDGHSNVLQ DCMRHHSSLV EVGKMWSNLH DRYGQLVALY TRLLCTKMEF HSKHSEIPPN
LEATDEVLER TAGTDINNVF QLTVEVFDYM DGELRLAETV IRQLNTSIAI STLTSGQCRL
APLIQVIQDC SHLYHFTVKL LFKLDINILV CLTRFPLSHS LKTFFNKARD MLYFKRLIQI
PKLPDSPPNF LHAASLAKHV KPVVVIPDED EPEQQDDDDD DPEPLIEVSN VSTPSLQAQP
QQLDIFDQAF GPPNGGFDDR DLQIESLKRD LELLRAELER VKAEAQRYIT QLKSQINSLE
AELEEQRAQK QRALVENEQL RMELEATRRR NAENEGLQTN FIEAEKRAQA TEQRYNKLKD
KHSELVASHA ELLRKSADTV RMLSATQQTQ EEVERTKQQL SFEVDRIKQE ADMKLEEQKF
EMDKLKRELE EKLAEVMRIK AVLQSSEKVS VHLWFLNAEK ERLMRSVSEK EAELSSLRQT
AQVQQSSLQQ ERERSSKELG ELQSKLQEKV SQDIRAQLSR QKLLEEQFTL LQGTITEAEN
IIQDAVAKLD DPLHVRCTSS PDYLISRAEA TLGSIDKVKK GHADYLHNMG DAGGLLRALT
QFSHLAADTI INGSATAHMA PTDHADRLTE NCRGCATQSL QYLKDLKSKA TLQKADPAAI
RIIIQKILHL GQELRPKSMD VRQDELGDLV DKEMAATSAA IEEAVRRIDE MMNQARKDTS
GVKLEVNERI LNSCTDLMKA IRMLVIASTD LQKEIVEGGR GAATIKEFYA RNSRWTEGLI
SAAKAVGWGA TEMVESADKV VLHTGKYEEL IVCSHEIAAS TAQLVAASKV KADRNSKKLS
VLQQASRHVN EMAANVVAST KTGQENLEEK ETMDFSGMSL IKLRKEEMES QVKVLELESQ
LDNERLRLGE LRKKHYELAG VPPGQISEGN GEASSLTLNA SMSPKPNKPV LMKKPALAQK
PHIPPKVRPV TKTLFCRGMY NSQLA
//
