ID   A0A667X6H5_9TELE        Unreviewed;      1179 AA.
AC   A0A667X6H5;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 3 {ECO:0000313|Ensembl:ENSMMDP00005010842.1};
OS   Myripristis murdjan (pinecone soldierfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Holocentriformes; Holocentridae; Myripristis.
OX   NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005010842.1, ECO:0000313|Proteomes:UP000472263};
RN   [1] {ECO:0000313|Ensembl:ENSMMDP00005010842.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A667X6H5; -.
DR   Ensembl; ENSMMDT00005011172.1; ENSMMDP00005010842.1; ENSMMDG00005004821.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   InParanoid; A0A667X6H5; -.
DR   Proteomes; UP000472263; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00089; PKD; 2.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1075..1093
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          797..866
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          26..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1179 AA;  133149 MW;  6602873D3CAA4117 CRC64;
     SPPLSSPLSL ISAGTPAEDA LQFAEDASLD GVSAKEHAAW SSPDEETHRD SNQEGKPEMG
     EDAALRRAKR SGPEFAEFSE SGWTGRAGVD ADASDERGNP GPLLDGHKLG RSDFRWNRDE
     GRGHNRQEEP KLTSSTFSLT GDSAHNHAVV YWSGQNSSVI LILTKLYDFH IGSVTESTLW
     RSTDYGSTYE RMNDKVGSKT VLSYLYVCPT NKRKIMVLTD PEFESSVLIS SDEGASYQKY
     RLSFYILSLL FHPTEEDWAL AYSHDQKLYS SMDFGRKWQL VHEHVTPNRF YWSVSGLDKE
     PDLVHMEAHA PDGNVQYVTC RAQMCTEPNR NYPFFGYIDI SSLVVQDDYI FIQVPTSGRA
     TYYVSYKRDP FIQIKLPKYS LPKDLHIVST DEKQVFAAVQ EWNQNDTYNL YLSDTRGIYF
     TLAMENVKTT RGIGGNQMLD LYEVAGIKGM LIANKRQDSQ VKTYITYNKG RDWRLLQAPA
     VDLDGNDIHC ILPFCSLHLQ LQMSENPYLS GTISTKSSAP GIIVATGNIG AELSYNNVGM
     FISSDAGNSW RQIFEEEHNV WFLDKGGALV AVKQPSVPTR HLWVSFDEGR QWTRHSFSLV
     PLFVDGVLVE AGAENQIMTF FGHFSHRSEW QLIKIDYKSI FTRRCTEEDY QTWHLHNQGE
     PCVMGQKQIY MKRRPGNFCM LGKDYSRILS AESCICRAHD FECDYGYERR ADGNCRAAFW
     FNPSTVSRSC SQGQNYLNST GYRKVVLNNC TKGVKEMYTA RKQQCPNRPP KGLALTTRDG
     KLTANLGNNV TFLVQLEEGD SMRTNIQLDF GDGTAVSYSN LSWTEEGIKH VYKSAGIFRV
     TALAENTLGY DTTTLYLHVT CPVEHVQLLA PFVVIRNKEV NITAMVWPSH SRTVTYFWWL
     GNNTEPVITL DGSISYTFPS EGMHTITVQV SSANTILQDT KTIAVQEFFK SLLLSFSPNL
     DEFNPDIPEW RQDVGRVIKK ALLQVSDFPE EQLLVAVFPG VPTAAELFLL PHKNHSEGKK
     KSEEELERVS EIIVSALNQN LVEFELKPGA RVIVYITQLT LAPLVDSSPR HSSSAMLMLL
     SVVFLGLAVF LIYKFKRKIP WINIYAEVNQ EKEQEMIGSV GQGDSTPKIT LSEFSTSKEL
     MEKELDARVK LFWNCTRVYF AEPKAARVTS WSGNEILGH
//