ID A0A667Y8Y6_9TELE Unreviewed; 365 AA.
AC A0A667Y8Y6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 13 {ECO:0000256|ARBA:ARBA00015732};
DE AltName: Full=26S proteasome regulatory subunit RPN9 {ECO:0000256|ARBA:ARBA00029749};
DE AltName: Full=26S proteasome regulatory subunit S11 {ECO:0000256|ARBA:ARBA00032323};
DE AltName: Full=26S proteasome regulatory subunit p40.5 {ECO:0000256|ARBA:ARBA00031303};
GN Name=psmd13 {ECO:0000313|Ensembl:ENSMMDP00005026575.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005026575.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005026575.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. {ECO:0000256|ARBA:ARBA00002362}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). The regulatory particle is made of a lid
CC composed of 9 subunits including PSMD13, a base containing 6 ATPases
CC and few additional components. {ECO:0000256|ARBA:ARBA00011441}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S11 family.
CC {ECO:0000256|ARBA:ARBA00006207}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A667Y8Y6; -.
DR Ensembl; ENSMMDT00005027131.1; ENSMMDP00005026575.1; ENSMMDG00005012422.1.
DR GeneTree; ENSGT00390000001802; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProt.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR035298; PSMD13.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10539; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13; 1.
DR PANTHER; PTHR10539:SF0; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000472263}.
FT DOMAIN 173..327
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 365 AA; 41714 MW; 8C536EA1619F24D9 CRC64;
MKDVTGYLKQ QQSNSSTPEM AAEWHTLEDL YNKKLWHQLT LKLTEFVKDP CFKTGDGLIQ
LYDNFLSDFE HRINPLSLVE IILYVARQMP DPKDAITFLE KTKEKVKSSE EAVILCKTSI
GSLKLEINDL PATKKIIEEV EEMLNNLPGV TSVHGRFYDL SSKYYRIIGN HAAYYKDALR
YLGCVDIKDL PETEKQERAF TLGLAGLLGE GVYNFGELLM HPVLESLRST DKQWLIDTLY
AFNGGNVEKF QSFKSAWGQQ VINNCITTMT FTRPANHRQL TFHEIAQSAK IPVSEVELLV
MKALSVGLIK GNIDEVDQKV QMTWVQPRVL DLQQIKGMKE RLDFWCGDVK NMAMLVEQQA
HDILT
//
