ID A0A667Y987_9TELE Unreviewed; 435 AA.
AC A0A667Y987;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Phosphatidylcholine-sterol acyltransferase {ECO:0000256|ARBA:ARBA00040526};
DE EC=2.3.1.43 {ECO:0000256|ARBA:ARBA00039142};
DE AltName: Full=Lecithin-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00042279};
DE AltName: Full=Phospholipid-cholesterol acyltransferase {ECO:0000256|ARBA:ARBA00041412};
GN Name=LOC115360944 {ECO:0000313|Ensembl:ENSMMDP00005024197.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005024197.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005024197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-
CC acyl-sn-glycero-3-phosphocholine + a sterol ester;
CC Xref=Rhea:RHEA:21204, ChEBI:CHEBI:15889, ChEBI:CHEBI:35915,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=2.3.1.43;
CC Evidence={ECO:0000256|ARBA:ARBA00036617};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR AlphaFoldDB; A0A667Y987; -.
DR Ensembl; ENSMMDT00005024719.1; ENSMMDP00005024197.1; ENSMMDG00005011660.1.
DR GeneTree; ENSGT00940000160052; -.
DR InParanoid; A0A667Y987; -.
DR OrthoDB; 353098at2759; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF18; PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE; 1.
DR Pfam; PF02450; LCAT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..435
FT /note="Phosphatidylcholine-sterol acyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025663422"
SQ SEQUENCE 435 AA; 50089 MW; E08E808323C63154 CRC64;
MGPTGRCCLA LLSIFLLGLH HASAFWLVDV LFPPSAKPRA SGNSSTPPLI IVPGNLGNRL
EAKIDKPALV HWMCYKKTEH WFPLWIDLNM LMPIGVDCWI DNIRIVYNRT TRRTSNSPGV
EVRVPGFGQT YPIEFLDYNR LTGYFHTMVE HLVNVGYIRN ETVRGAPYDW RVAPNENGEY
LSRLQDLVEE MYDQYQQPVY LLGHSMGCHY VLYFLNHQPQ AWKDKYIKGF ISLGAPWGGA
VKTLRVIASG ENDGIPMISN IKIREEQRMT TTNPWMLPYD NAWPKDHVFI STPSFNYTSK
DYQRFFKDID FEDGWYMWED TKNLTADLKP PGVEVWCMYG VGLPTPVTYI YDEEFPNADP
VDIVYADGDD TVDSFSMSLC KRWEGRQDEP VHVTEFRGMP HLEMVFHEKV LSQIQHILEG
NSDTPKEVDC RPGQI
//
