ID A0A667YP55_9TELE Unreviewed; 337 AA.
AC A0A667YP55;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Ileal sodium/bile acid cotransporter {ECO:0000256|ARBA:ARBA00013351};
DE AltName: Full=Apical sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00032438};
DE AltName: Full=Ileal Na(+)/bile acid cotransporter {ECO:0000256|ARBA:ARBA00033223};
DE AltName: Full=Ileal sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00030792};
DE AltName: Full=Na(+)-dependent ileal bile acid transporter {ECO:0000256|ARBA:ARBA00033014};
DE AltName: Full=Solute carrier family 10 member 2 {ECO:0000256|ARBA:ARBA00031381};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005029707.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005029707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) +
CC tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133064; Evidence={ECO:0000256|ARBA:ARBA00034255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) +
CC tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191406; Evidence={ECO:0000256|ARBA:ARBA00034234};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) +
CC taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00034224};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) +
CC taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00034239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) +
CC taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36261; Evidence={ECO:0000256|ARBA:ARBA00034280};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) +
CC tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191405; Evidence={ECO:0000256|ARBA:ARBA00034291};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) +
CC tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:132028; Evidence={ECO:0000256|ARBA:ARBA00034230};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747;
CC Evidence={ECO:0000256|ARBA:ARBA00034231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29746; Evidence={ECO:0000256|ARBA:ARBA00034215};
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|ARBA:ARBA00011407}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A667YP55; -.
DR Ensembl; ENSMMDT00005030402.1; ENSMMDP00005029707.1; ENSMMDG00005014105.1.
DR GeneTree; ENSGT00950000182808; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361:SF19; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 27..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 337 AA; 36571 MW; C6D56E2526274214 CRC64;
LCLVCLSNAT VCSGTDCLVP PSNFNDILSL VLSIVLTTML AMVMFAMGCT VDAKKLWGHI
KRPWGIFIGF LCQFGIMPFT AFALSLAFNV LPVQAIVIII MGCCPGGSSS NIICFWLDGD
MDLSISMTAC SSILALGMMP LCLLIYTSLW TSADTIQIPY DSIGITLVSI LIPVALGMYL
KHKKPLLAKK VLKVGSIVGF ALIIIIAVVG GVLYQSSWTI APSLWIIGTI YPFIGFGLGF
GLARFVGQPW YRCRTIALET GFQNAQLCST IVQLSFSPAE LEVMFAFPLI YSIFQLVVAL
MSVGGESLTC RHTNSQGWAF QQISLFQVII KTRLSLI
//
