ID A0A667ZP10_9TELE Unreviewed; 312 AA.
AC A0A667ZP10;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Pro-cathepsin H {ECO:0000256|ARBA:ARBA00039372};
GN Name=LOC115378907 {ECO:0000313|Ensembl:ENSMMDP00005044640.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005044640.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005044640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Important for the overall degradation of proteins in
CC lysosomes. {ECO:0000256|ARBA:ARBA00037522}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins, acting as an aminopeptidase (notably,
CC cleaving Arg-|-Xaa bonds) as well as an endopeptidase.; EC=3.4.22.16;
CC Evidence={ECO:0000256|ARBA:ARBA00036517};
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A667ZP10; -.
DR Ensembl; ENSMMDT00005045527.1; ENSMMDP00005044640.1; ENSMMDG00005020136.1.
DR GeneTree; ENSGT00940000160227; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..312
FT /note="Pro-cathepsin H"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025586844"
FT DOMAIN 15..66
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 92..309
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 312 AA; 34874 MW; 3176552BBA572FC2 CRC64;
MAPGAFVCFI SLSVLGLHNK VYEIEEYYHR LQIFTENKRN IDRHNAGNHS FTMGLNQFSD
MTSEEFRKSV LLTEPQNCSA TKGSHVSRNG PYPEFVDWRK RGNFVSPVKN QGHCGSCWTF
STTGCLESVT AIATGKLLLL SEQQLIDCAQ DFNNHGCMGG LPSQAFEYIK YNNGLMTEDD
YPYKGHDDTC HFKSTLAAAF VKDVVNITSY DENGMVDAVA RLNPVSFGYQ VTADFMHYKE
GVYTSTRCKN TTDMVNHAVL AVGYGATENG MPYWIVKNSW GTAWGMEGYF LIERGKNMCG
LAACSSYPLP LF
//
