ID A0A667ZRM6_9TELE Unreviewed; 449 AA.
AC A0A667ZRM6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Serine incorporator 1 {ECO:0000256|ARBA:ARBA00040945};
DE AltName: Full=Tumor differentially expressed protein 2 {ECO:0000256|ARBA:ARBA00041691};
GN Name=serinc1 {ECO:0000313|Ensembl:ENSMMDP00005035496.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005035496.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005035496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC and sphingolipids. {ECO:0000256|ARBA:ARBA00037552}.
CC -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000256|ARBA:ARBA00011492}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
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DR AlphaFoldDB; A0A667ZRM6; -.
DR Ensembl; ENSMMDT00005036274.1; ENSMMDP00005035496.1; ENSMMDG00005015798.1.
DR GeneTree; ENSGT01030000234623; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF15; SERINE INCORPORATOR 1; 1.
DR Pfam; PF03348; Serinc; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 449 AA; 49759 MW; 8874ADC20959B4D6 CRC64;
LGVIPCLCGS APCLLCRCCP SGNNSTVTRL IYAFFLLLGV GIACIMLMPG MEGQLKKIPG
FCEGGMGSSI PGVEGHVNCD VLVGYKAVYR VCFGMAMFFL LFSLLMIKVK SSQDPRAALH
NGFWFFKFAA AAAITIGAFF IPEGPFTTVW FYIGMAGAFC FILIQLVLLI DFAHSWNESW
VEKMEEGNSR CWYAALLSAT TVNYLLSLVS LVMFYVYYTH SDGCTENKAF ISVNMLLCVA
ASVMSILPQI QESQPRSGLL QSSLVTLYTM YLTWSAMTNE PDRKCNPSLL GIIGLNSTSP
AGQDHVVQWW DAQGIVGLIL FLMCVLYSSI RNSSNAQVNK LTLTSDESAL IEDGPQSDSF
EEGDGLNRAV DNEKDGVTYS YSFFHFMLFL ASLYIMMTLT NWYSPDSNYE TMTSKWPSVW
VKISSSWICI ALYVWTLVAP LVLVNRDFD
//
