ID A0A668A4B6_9TELE Unreviewed; 711 AA.
AC A0A668A4B6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 4 {ECO:0000313|Ensembl:ENSMMDP00005048117.1};
GN Name=hsd17b4 {ECO:0000313|Ensembl:ENSMMDP00005048117.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005048117.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005048117.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR AlphaFoldDB; A0A668A4B6; -.
DR Ensembl; ENSMMDT00005049065.1; ENSMMDP00005048117.1; ENSMMDG00005018031.1.
DR GeneTree; ENSGT00940000158343; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263}.
FT DOMAIN 467..580
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 606..706
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 711 AA; 77239 MW; 15D7302FC56A6CED CRC64;
MRVEIQCVLI TFNVGRELQN APHYCQSFAS CCNTVNDLGG DIKGGGKSSA AADKVVEEIR
AKGGKAVANY DSVEDGEKLI QTALDAFGKI GMILRDRSFA RTSDLDWDLI HRVHLRGAFM
VTRAAWNHMK NQKFGRIIMT ASTAGIYGNF GQANYSAAKL GLYGLANTLA IEGRKYNIHC
NTIAPTAGSR LTQSVMPPDL VESMKPEYVA PLVLWLCHEQ CKENGGLFEV GGGWIGKLRW
ERSQGHIVRH KNQRMTPEAV RDHWDNICDF TDAAKPVSIQ EGLQMVVEVL SKVDSEGGVS
GNPTASAASA VGQKLPPTSF SFSHTQCIIY ALGVGMSTKD PDHLRFLYEG HEDFSCLPTF
GVIPSQAAMM DGGLASVPGL NIDFTRVLHG EQYLELYKPL PTSGTLTSQA TVADVLDKGS
GAVILLDVNT YSGDELVCYN QWSVFVVGAG GFGGKRTSDR AKALVPPPNR APDAVVTDST
TRDQAALYRL SGDWNPLHID PSFAAMGGFK APILHGLCSF GFAARHVLKQ YANNDPSRFK
AIKVRFVKPV LPGQSLQTEM WKEGNRIHIQ CKVKETDAVV LSGAYVDLHG AAEGGGLQSE
LVFAEIGRRI KDLGSELVKK VNAVFGWEIT KNGKTAAQWT IDLKSGTGSL HKGPYSGKAD
VTFTVSDEDF MEVVQGKLNP QKAFFAGKLK VRGNIMMSQK LEVILKDYAK L
//
