ID A0A668AAU8_9TELE Unreviewed; 1071 AA.
AC A0A668AAU8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|Ensembl:ENSMMDP00005050572.1};
GN Name=SLC12A6 {ECO:0000313|Ensembl:ENSMMDP00005050572.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005050572.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005050572.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A668AAU8; -.
DR Ensembl; ENSMMDT00005051568.1; ENSMMDP00005050572.1; ENSMMDG00005021667.1.
DR GeneTree; ENSGT00940000160238; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..646
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..306
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 423..711
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 725..842
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 858..1071
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 954..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 118413 MW; 25C8880E701007AB CRC64;
MKCFVFEAES GLEINFALYG SHTGCCYQKS SLFLLHQSDA EPQNGGCLSA AVSVSVQLRP
KITSVWLVAG VNLLPLEEMD TRPKVSSLLN RLANYTNLTQ GAKEHEEAES IGEKRKTGKS
PQMGTFMGVY LPCLQNIFGV ILFLRLTWVV GTAGVLQGLC IVFICCCCTM LTAISMSAIA
TNGVVPAGGS YFMISRSLGP EFGGAVGLCF YLGTTFAGAM YILGAIEILL MYIAPSTAIF
VPSSPDGEGA AMLNNMRVYG SICLLLMSLL VFVGVKYVNK LASIFLACVI ISILSIYIGA
LISAFSPPKF PVCMLGNRTI NGHTLRDHQC AKTVLLQIKE PAGKATVLWE HFCEGKELNS
SCDDYFSHSN FTQIEGIPGL ASGIITENLW SSYLSKGDVL EKSSLNSTHT AHPASFQQPY
VFADITTSFT LLVGIFFPSV TGIMAGSNRS GDLKDAQRSI PIGTILAILT TSLVYLSSVI
LFGACIDGVL LRDKFGDSVK GNLVVGTLAW PSPWVIVIGS FFSTCGAGLQ SLTGAPRLLQ
AIAKDNIIPF LRFHSAHLHV FGHGKANGEP TWAMLLTALI AELGILIASL DLVAPILSMF
FLMCYLFVNL ACALQTLLRT PNWRPRFSYY HWTLSFLGMT ICLALMFISS WYYAIVAMVI
AGMIYKYIEY HGAEKEWGDG IRGLSLSAAR YALLRLEEGP PHTKNWRPQL LVLLKLDEDA
HVKSPRLLTF ASQLKAGKGL TIVGTVIPGN FLHSYGEALA AEQTMKHLMD KERVKGFCQC
IVAQKPRDGI SHMIQSSGLG GMKHNTVVMG WPHAWRQSED PQSWKTFINT VRVTTAAHLA
LLVPKNISLF PSNNEPCTEG YIDVWWIVHD GGMLMLLPFL LRQHKVWRKC GMRIFTVAQM
EDNSIQMKKD LATFLYHLRI EAEVEVVEMH DSDISAYTYE RTLMMEQRSQ MLRQMRLSKS
DREKEVSLRR PREKSASSSA EHHRRVQMTW TKEKTMQDHS NVRRMHTAVK LNEVIVNKSH
DARLVLLNMP GPPRNPEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S
//
