ID A0A668ARM9_9TELE Unreviewed; 973 AA.
AC A0A668ARM9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSMMDP00005051169.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSMMDP00005051169.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005051169.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005051169.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A668ARM9; -.
DR Ensembl; ENSMMDT00005052175.1; ENSMMDP00005051169.1; ENSMMDG00005022571.1.
DR GeneTree; ENSGT00940000158642; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 455..628
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 676..773
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 857..954
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 802..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 557..587
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 814..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 112276 MW; 6C9B7DF6237720C2 CRC64;
MGEIEGSYRV LQTPGTRLGA QFNAGISTLE PGQSLSANMA TGAKSHGRGL QIRVLGLDDS
QEFFDIEPKA FGQALLSEVF QRGNLIESDY FGLEFQNMQM NWVWLEPTKP IIKQVRRPTN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLMEGRLT CTENTGALLA SHLVQSEIGD
YDDMADRDFL RVNKLLPYQD RVLEKILDLH RRHMGQTPAE SDFQVLEIAR KLEMYGVRFH
PAADREGTKI NLAVAHMGLQ VFQGNTKINT FNWSKIRKLS FKRKRFLIKL HPEVHGPHQD
TLEFLMASRD QCKIFWKNCV EHHSFFRLFD QPQPKSKAIL FTRGSSFRYS GRTQKQLVEY
VRDSGAKRTP YQRCVFLCTC NVVISSTGSA MDSPQLSPFV TKSPLCLSPS FQMSTLSLPG
QAPSPLQSPI LSEVGSNARL EEEEEGRRKR YPTDKAYFIA KEILTTERTY LKDLEVITVW
FRSAVIKENA MPEGLMTLLF SNIDPIYEFH RGFLKEIDQR LALWEGRSNA HVKGDYQRIG
DVMLRNMSAL KEFTSYLQKH DEVLTELEKA TKRLKKLETV YKEFELQKVC YLPLNTFLLK
PIQRLMHYKL ILERLCKHYS PAHRDHDDCK GEILHLICQW SSKLQSSLIR LENFQKLTEL
QRDLIGIENL TTPGREFIRE GCLYKLTKKG LQQRMFFLFS DMLLYTSKGV TATNQFKVHG
QLPLHGMIVE ESENEWSVPH CFTIYSAQRT IVVAASSKVE MGKWIEDLNM AIDMAKKSTV
YPFPPHNFLP LPLPTSFLLP SSGSSDEVSL EQESEDDMHS SRTSLDKQTH HRANTTMHVC
WHRNTSVSMS DHSLAVENQL SGYLLRKFKN SNGWQKLWVV FTNFCLFFYK THQDDFPLAS
LPLLGYTVCT PEESDSIHKE YVFKLQFKSH VYFFRAESEY TFERWMEVIK SAASTTGRMS
LLIPKGPMEI NGN
//
