ID A0A668AWP6_9TELE Unreviewed; 963 AA.
AC A0A668AWP6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSMMDP00005051401.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSMMDP00005051401.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005051401.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005051401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A668AWP6; -.
DR Ensembl; ENSMMDT00005052413.1; ENSMMDP00005051401.1; ENSMMDG00005022571.1.
DR GeneTree; ENSGT00940000158642; -.
DR Proteomes; UP000472263; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 456..647
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 676..773
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 847..944
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 796..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 558..588
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 963 AA; 110901 MW; 48AC47861E0318C4 CRC64;
MGEIEGSYRV LQTPGTRLGA QFNAGISTLE PGQSLSANMA TGAKSHGRGL QIRVLGLDDS
QEFFDIEPKA FGQALLSEVF QRGNLIESDY FGLEFQNMQM NWVWLEPTKP IIKQVRRPTN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLMEGRLT CTENTGALLA SHLVQSEIGD
YDDMADRDFL RVNKLLPYQD RVLEKILDLH RRHMGQTPAE SDFQVLEIAR KLEMYGVRFH
PAADREGTKI NLAVAHMGLQ VFQGNTKINT FNWSKIRKLS FKRKRFLIKL HPEVHGPHQD
TLEFLMASRD QCKIFWKNCV EHHSFFRLFD QPQPKSKAIL FTRGSSFRYS GRTQKQLVEY
VRDSGAKRTP YQRCVFLCTC NVVISSTGSA MDSPQLSPFV TKSPLCLSPS FQMSTLSLPG
QAPSPLQSPI LSEVGSNLCG FDTKCPLLPQ RYPTDKAYFI AKEILTTERT YLKDLEVITV
WFRSAVIKEN AMPEGLMTLL FSNIDPIYEF HRGFLKEIDQ RLALWEGRSN AHVKGDYQRI
GDVMLRNMSA LKEFTSYLQK HDEVLTELEK ATKRLKKLET VYKEFELQKV CYLPLNTFLL
KPIQRLMHYK LILERLCKHY SPAHRDHDDC KDALKEVADI AAQLQSSLIR LENFQKLTEL
QRDLIGIENL TTPGREFIRE GCLYKLTKKG LQQRMFFLFS DMLLYTSKGV TATNQFKVHG
QLPLHGMIVE ESENEWSVPH CFTIYSAQRT IVVAASSKVE MGKWIEDLNM AIDMAKKSQE
KSNIFLDAGL GDRSSDEVSL EQESEDDMHS SRTSLDKQTH HRANTTMHVC WHRNTSVSMS
DHSLAVENQL SGYLLRKFKN SNGWQKLWVV FTNFCLFFYK THQDDFPLAS LPLLGYTVCT
PEESDSIHKE YVFKLQFKSH VYFFRAESEY TFERWMEVIK SAASTTGRMS LLIPKVGILQ
GKR
//