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Database: UniProt
Entry: A0A668AZ72_9TELE
LinkDB: A0A668AZ72_9TELE
Original site: A0A668AZ72_9TELE 
ID   A0A668AZ72_9TELE        Unreviewed;      1077 AA.
AC   A0A668AZ72;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSMMDP00005054381.1};
GN   Name=SLC12A4 {ECO:0000313|Ensembl:ENSMMDP00005054381.1};
OS   Myripristis murdjan (pinecone soldierfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Holocentriformes; Holocentridae; Myripristis.
OX   NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005054381.1, ECO:0000313|Proteomes:UP000472263};
RN   [1] {ECO:0000313|Ensembl:ENSMMDP00005054381.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC         Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034453};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A668AZ72; -.
DR   Ensembl; ENSMMDT00005055429.1; ENSMMDP00005054381.1; ENSMMDG00005023724.1.
DR   GeneTree; ENSGT00940000157672; -.
DR   Proteomes; UP000472263; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR000076; KCL_cotranspt.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 2.
DR   Pfam; PF03522; SLC12; 3.
DR   PRINTS; PR01081; KCLTRNSPORT.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT   TRANSMEM        118..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        520..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        544..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        577..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..261
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          359..659
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          673..791
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          805..876
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          968..1077
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1077 AA;  119670 MW;  2CF07911F20131C7 CRC64;
     FCQSFYVTSV PFLNSTDATK KNDFYDKNLA LFEEELDIRP KVSSLLSRLV NYTNITQGAK
     EHEEEESAEA SLRKAPKSPN MGTLMGVYLP CLQNIFGVIL FLRLTWIVGT AGIVQSLLIV
     LMCCSCTMLT AISMSAIATN GVVPAGGAYF MISRSLGPEF GGAVGLCFYL GTTFAAAMYI
     LGAIEIFLKY LVPQGTMTIF HATDPHGGDS AMLNNMRVYG SLCLSLMAVV VFVGVKYVNK
     LASLFLACVI ISIVSIYAGA IKSITHPPEF PICMLGNRTL VRDFDVCAKT VVQGNYTVPS
     NLSEKFCPLG NMSSAQCDEY FSQNNVTEVQ GIPGLASGII RENMWGDYLQ KGEILEKAGL
     QSVDVHGAME NFAMYVSADI ATSFTLLVGI FFPSATGIMA GSNRSGDLRD AQKSIPVGTI
     LAITTTSLVY FSSVVLFGAC IEGVVLRDKF GDAVSNNLVV GTLSWPSPWV IVIGSFFSTV
     GAGLQSLTGA PRLLQAIAKD NIIPFLRVFG HGKANGEPTW ALLLTGLIAE LGILIASLDM
     VAPILSMFFL MCYLFVNLAC AVQTLLRTPN WRPRFKYYHW ALSFLGMSMC LALMFISSWY
     YAIVAMGIAG MIYKYIEYQG AEKEWGDGIR GLSLSAARYA LLRLEVGPPH TKNWRPQLLV
     LLKLDEDLHV KYPRLLTFAS QLKAGKGLTI VGSVIQGNFL DSYGETQAAE QAIKNMMEIE
     RVKGFCQVVV ASKVREGIAH LIQSCGLGGM KHNTVVMGWP YGWRQSEDPR AWKTFINTVR
     CTTAAHLALM VPKNVSFYPS NHERFTDGNI DVWWIVHDGG MLMLLPFLLK QHKVWRKCKM
     RIFTVAQMDD NSIQMKKDLA TFLYQLRIEA EVEVVEMHDS DISAYTYERT LMMEQRSQML
     RQMRLSSAER DREVCLSFLQ IYTCLCIEYG VSSCSLGPLQ AQLVKDRHSL IRMGSLYSDE
     EEEVAEPPPE KVQMTWTKEK CEAERRNRNN TPENFRELIS LKPDQSNVRR MHTAVKLNEV
     IVNRSHDARL VLLNMPGPPR NTDGDENYME FLEVLTEGLE RVLLVRGGGR EVITIYS
//
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