ID A0A669BBG2_ORENI Unreviewed; 731 AA.
AC A0A669BBG2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=TRMT1-like protein {ECO:0000256|ARBA:ARBA00015939};
GN Name=TRMT1L {ECO:0000313|Ensembl:ENSONIP00000032826.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000032826.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000032826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in motor coordination and exploratory
CC behavior. {ECO:0000256|ARBA:ARBA00003652}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000256|PROSITE-ProRule:PRU00958}.
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DR RefSeq; XP_019202843.1; XM_019347298.1.
DR AlphaFoldDB; A0A669BBG2; -.
DR Ensembl; ENSONIT00000092290.1; ENSONIP00000032826.1; ENSONIG00000007823.2.
DR GeneID; 100711758; -.
DR CTD; 81627; -.
DR GeneTree; ENSGT00530000063646; -.
DR InParanoid; A0A669BBG2; -.
DR OMA; HLPCHPV; -.
DR OrthoDB; 3146970at2759; -.
DR Proteomes; UP000005207; Linkage group LG17.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10631:SF1; TRMT1-LIKE PROTEIN; 1.
DR Pfam; PF02005; TRM; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00958};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; tRNA processing {ECO:0000256|PROSITE-ProRule:PRU00958};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW ProRule:PRU00958}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 198..225
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 731 AA; 80497 MW; 662B6D31A9399862 CRC64;
MIVGATGAQR RRAGEAWRLG VCQGDRRKTW SATQVGGVAV MDHWMFWTAS ETNISWCVAC
APATPTLAIS PFRLPSGGDG GDGPFVAEET LKSETATDAD AKPSITTAER HLSIQTKLEG
LEMLVDLSGA GRKSCPLCPE EKFKACYSHK LRRHLQNLHW KVYAEFEGYR MCICHLPCRN
VKPSLSGDHA SGRHVAHYHC VVCSVTIARK TDMISHLKRH VNKGETEASY SGTSDVLFEE
PSPSGQAYEI MKELGTNVQL LPNHTTPQKS DTYFNRKMKT NRQLVFCSLA VLAEERNPVE
CLDAFGATGI MGLQWAKHLL NAVRVTITDI SETCVKMIKE NCKLNNIRVD GGMRVPRGSD
GASGEVEGVP IATVEVAKMD ANVIMHLRPF DYIHLDPFGT AVNYLDAAFR NVRNLGIISV
TSTDTGSLYA KSPNVTLRHY GCHIVRTEYY RELAARMVVA TVARAAARCN KGIEVLLAVA
LEHFVLVVVR VLRGPVQADE SAKKLRKLMH CQWCEERVFL KLGNMVDDTL PCNCHGSLPG
KTAVQLGPLW SGPLFNTGFL RRMLSAAVKH SMDDIQPLVK TLIYESECTT LKSLVHGPSA
LTNQVECGVV IKTLNTGEES GAADQSGKRK IADESGNFVK KLKSDAALDH PPFYYSIHRH
SIRGMNMPKL NKFLQYLTEA GFRVSRTHFD PTGVRTDATL LQFKSVLTKY SVPTCTNASA
TQTSVSVEKT V
//
