ID   A0A669C6X2_ORENI        Unreviewed;       575 AA.
AC   A0A669C6X2;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=FERM domain containing 3 {ECO:0000313|Ensembl:ENSONIP00000042590.1};
GN   Name=FRMD3 {ECO:0000313|Ensembl:ENSONIP00000042590.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000042590.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000042590.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A669C6X2; -.
DR   Ensembl; ENSONIT00000050549.1; ENSONIP00000042590.1; ENSONIG00000015018.2.
DR   GeneTree; ENSGT00940000158577; -.
DR   Proteomes; UP000005207; Linkage group LG12.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17102; FERM_F1_FRMD3; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR   PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        498..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          18..298
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   575 AA;  66199 MW;  701255A16BF8ACDE CRC64;
     MKMLRFRSPS LRSLDQEILC TIRLLDDSEI SCSIQRDTRG QFLLDHVCNH YNLLEKDYFG
     IRYVDPEKQR HWLEPNKPVV RQMKSQQPYT MCFRVKFYPH EPMKIKEELT RYLLYLQLKR
     DIYHGRLLCP FAEAAYLGAC IIQAELGDYD PEEHPSDYIR DFKLFPKQSL KLERKIMEIH
     KNELRGQCAA LAELNMLQRA HSLETYGVDP HPCKDFTGST AFLGFTATGF VVFQGNKRIH
     LLKWADVSKL KFEGKTFYVI GIQKEKKLVL TFHTSTPAAC KHLWKCGVEN QAFYKCAKSS
     QIKTVSSSNI FFKGSRFRYS GRVAKEVIEA SSKIQREPPE VRRAQFGQSR SFNSLSHKNL
     IMNMEPLVPA LPSTNEYEET AMDSLEVPGE DNNQAKPPPT YRSAVCLLSL FSSPCASMLP
     TPVDDSQGGV DLLFSSPVQS PVRLLRELHA DPDIQAQLEA ERERDRAYER TRLAARSRMS
     GVLTSSLRLL SSNDRVNACV LSVARFVAVV MGVLLVTVPT LLLLLESDID VSFLHEIRQT
     PEFEQFHYEY YCPLRRWILC KIMYVLTCDL ILYLI
//