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Database: UniProt
Entry: A0A669D2H0_ORENI
LinkDB: A0A669D2H0_ORENI
Original site: A0A669D2H0_ORENI 
ID   A0A669D2H0_ORENI        Unreviewed;       958 AA.
AC   A0A669D2H0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSONIP00000054676.1};
GN   Name=scube3 {ECO:0000313|Ensembl:ENSONIP00000054676.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000054676.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000054676.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; A0A669D2H0; -.
DR   Ensembl; ENSONIT00000088033.1; ENSONIP00000054676.1; ENSONIG00000016993.2.
DR   GeneTree; ENSGT00940000153185; -.
DR   Proteomes; UP000005207; Linkage group LG20.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   CDD; cd00041; CUB; 1.
DR   CDD; cd00054; EGF_CA; 2.
DR   Gene3D; 2.10.25.10; Laminin; 9.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF07699; Ephrin_rec_like; 3.
DR   Pfam; PF14670; FXa_inhibition; 4.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00181; EGF; 10.
DR   SMART; SM00179; EGF_CA; 7.
DR   SMART; SM01411; Ephrin_rec_like; 4.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 6.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS01186; EGF_2; 6.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          11..51
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          264..304
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          305..343
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          344..384
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          768..880
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   DISULFID        309..319
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   958 AA;  106165 MW;  C7DFC547DDB38F1F CRC64;
     MPARADILQA YVDECAEALD NCSIDAICQN TLKSYKCICK SGYKGDGKHC EDVDECATEY
     NGGCVHECIN IPGNYRCTCY DGFRLAHDGH NCLDVDECSE GNGGCQQICV NMMGSYECRC
     REGFLLSDNQ HTCIQRPKDG TKNEGPTCMD KNHGCAHICR ETQKGGISCE CRPGFQLTRN
     MKDCKLTCNY GNGGCQHICE ETDQGPKCSC HMKFVLHSDG KTCVETCAVN NGGCDSTCHD
     SVTGVRCSCP VGFTLQPDRK TCKDIDECRL NNGGCDHVCR NTVGSFECSC KKGYKLLTNE
     RTCQDIDECS FDRACDHFCV NSAGSFQCHC HKGYVLYGLA HCGDIDECSI NRGGCKYGCV
     NTLGSYECTC PPGYKLHWNK KDCIEPVKCP PGLVAPKATL TCSKTGKKES CSLTCASKAH
     YLAGMSPKFR VQSQSISDPK DYVLLPTGLC LSVEALAPPV KQTASFKIKN AKCHLHPKLP
     GQPCSNCLVT FVNLKCDSSK KAKGRRARNP SNKEVTRITL ELEAEIKPTD ATGSCNLSCL
     RQRMEKQVKT YIKALKKSIN QERFLIRVAG LEYEVAQKLP QAAPIQENCG PGWERDSGRC
     VRCLPGSYYH GEQERCVQCP PGTFQEKEGQ LACDLCPGSD GHGPVGARNI SSCAGQCPTG
     YYSSSGFKPC LPCPQGYYQP DLGRTLCFPC GGGLNTKREG ASSFHDCEVK VDCSPGHYYN
     TTVHRCIRCP VGTYQTEFKQ NYCISCPGNT TTDFDGATSV SQCKNRQCGG EMGEFMGYIE
     SPNYPGNYPA NVECIWNINP PSKRKILIVV PEIFLPSEDE CGDVLVMRKN WSATSITTYE
     TCQTYERPIA FTARSRRLWI NFKSNEANSA RGFQIPYVTY DEDYEQLVED IVRDGRLYAS
     ENHQEILKDK KLIKTLFDVL AHPHNYFKYT TRESNELLPR SFIRLISSKV SAFLRPYK
//
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