ID A0A669D2H0_ORENI Unreviewed; 958 AA.
AC A0A669D2H0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSONIP00000054676.1};
GN Name=scube3 {ECO:0000313|Ensembl:ENSONIP00000054676.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000054676.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000054676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A669D2H0; -.
DR Ensembl; ENSONIT00000088033.1; ENSONIP00000054676.1; ENSONIG00000016993.2.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..51
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 264..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 305..343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 344..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 768..880
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 309..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 958 AA; 106165 MW; C7DFC547DDB38F1F CRC64;
MPARADILQA YVDECAEALD NCSIDAICQN TLKSYKCICK SGYKGDGKHC EDVDECATEY
NGGCVHECIN IPGNYRCTCY DGFRLAHDGH NCLDVDECSE GNGGCQQICV NMMGSYECRC
REGFLLSDNQ HTCIQRPKDG TKNEGPTCMD KNHGCAHICR ETQKGGISCE CRPGFQLTRN
MKDCKLTCNY GNGGCQHICE ETDQGPKCSC HMKFVLHSDG KTCVETCAVN NGGCDSTCHD
SVTGVRCSCP VGFTLQPDRK TCKDIDECRL NNGGCDHVCR NTVGSFECSC KKGYKLLTNE
RTCQDIDECS FDRACDHFCV NSAGSFQCHC HKGYVLYGLA HCGDIDECSI NRGGCKYGCV
NTLGSYECTC PPGYKLHWNK KDCIEPVKCP PGLVAPKATL TCSKTGKKES CSLTCASKAH
YLAGMSPKFR VQSQSISDPK DYVLLPTGLC LSVEALAPPV KQTASFKIKN AKCHLHPKLP
GQPCSNCLVT FVNLKCDSSK KAKGRRARNP SNKEVTRITL ELEAEIKPTD ATGSCNLSCL
RQRMEKQVKT YIKALKKSIN QERFLIRVAG LEYEVAQKLP QAAPIQENCG PGWERDSGRC
VRCLPGSYYH GEQERCVQCP PGTFQEKEGQ LACDLCPGSD GHGPVGARNI SSCAGQCPTG
YYSSSGFKPC LPCPQGYYQP DLGRTLCFPC GGGLNTKREG ASSFHDCEVK VDCSPGHYYN
TTVHRCIRCP VGTYQTEFKQ NYCISCPGNT TTDFDGATSV SQCKNRQCGG EMGEFMGYIE
SPNYPGNYPA NVECIWNINP PSKRKILIVV PEIFLPSEDE CGDVLVMRKN WSATSITTYE
TCQTYERPIA FTARSRRLWI NFKSNEANSA RGFQIPYVTY DEDYEQLVED IVRDGRLYAS
ENHQEILKDK KLIKTLFDVL AHPHNYFKYT TRESNELLPR SFIRLISSKV SAFLRPYK
//