ID A0A669DH17_ORENI Unreviewed; 892 AA.
AC A0A669DH17;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|Ensembl:ENSONIP00000058185.1};
GN Name=LOC100700766 {ECO:0000313|Ensembl:ENSONIP00000058185.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000058185.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000058185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A669DH17; -.
DR Ensembl; ENSONIT00000080432.1; ENSONIP00000058185.1; ENSONIG00000007896.2.
DR GeneTree; ENSGT00940000155044; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF97; SLC12A10.3 SOLUTE CARRIER FAMILY 12 (SODIUM_POTASSIUM_CHLORIDE TRANSPORTERS), MEMBER 10, TANDEM DUPLICATE 3 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 56..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..42
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 65..567
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 576..671
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 707..891
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 892 AA; 99750 MW; 8B0B828B795DFF64 CRC64;
MEPRKTSIYN TIDMAPQLEY YANTLPHQEI KIRPSLDVLR KTFEVSFPPV EKNISLLSFF
LTLQLMRCML NIWGVILFLR LTWITSQAGI VLGLVIIALA VSVTTTTALS ISAIATNGES
GTYFMISRTL GPELGASIGL IFSLANALAV ALHTVGFSEV VRDLMRSYGT IMVDSLNDVR
IIGVVTVTIL LFITFGGMDW EAKAQIFFFI VLMASFVDYL VGTLIPPTPL KKSQGFFGYD
RDIFIENLTP SWRGPDGNFF RQFAIFFPAC TGILSGANIS GDLKDPSTAI PKGTLMAIFC
TTLSYVVIVI TSGASTVRDA SGNMTDLMTG NSTSGCLGPA CKLGWNFTTC VQSQTCSQGL
ANYSQVMGLI SGSYYLIVAG VFAATLSSAL GFLVSAPKIF QCLCKDNVYP YISFFGKGYG
KNNEPLRGYI LTYLIAVAII LVAQLNIIAP IISNFFLCSY CLINLSCFHA SIVNSPGWRP
AFKYYNKWTA LYGAMASFAL MFAFTWWAAL GTWFVISLLF IYITYFKRPN VNWGSSIQAS
SYNMALSFSV SLTDVKDHVK NFRPQCLVMT GPPKQRPALV DFVGCFTKQV SLMICGNIIM
EPDKQTQFQD STDQYVKWLN KRKVRSFYTQ FTADTLRDGV RYLMQASGLG KLKPNTLVIG
FKSKWMESSP TTYHFFHTLC VRIILFNLYD NTYLLLFAAN DISENSDQVK TVFKNAGGTK
TIDVYWIADD GGLIVLVPYL LTRRKRWRSC KIRVFILGDE ENMKESRDAK IICVFLMPCS
MNKFLESVAP YRLYDEQQEG VSVQELKKKE PWKISDKQFE AFRLKSERKV RLNEIIRRNS
QNTTLVLVLP VAHGDCPSAL YIAWLDALTC GLHCPAVLVR GNQENVLTFY CQ
//
