ID A0A669E4V9_ORENI Unreviewed; 531 AA.
AC A0A669E4V9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Phosphatidylinositol-binding clathrin assembly protein {ECO:0000313|Ensembl:ENSONIP00000066086.1};
GN Name=LOC109194194 {ECO:0000313|Ensembl:ENSONIP00000066086.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000066086.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000066086.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR AlphaFoldDB; A0A669E4V9; -.
DR Ensembl; ENSONIT00000068074.1; ENSONIP00000066086.1; ENSONIG00000006985.2.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF11; ENTH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 447..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..341
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 458..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 59290 MW; 647370DAD401408D CRC64;
MSGQSITDRI TAAQHSMTGS AISKAVCKAT THEVSGPKKK HLDYLIHCTN EMNVNIPQLA
DTLFERTANS SWVVVFKALI TTHHLMMYGN ERFIQYLASR NTLFNLNNFL DKGALQGYDM
STFIRRYSRY LNEKAMSYRL VAVDFTKMKR GIDGVMRTMN TEKLIKTLPI IQNQLDALLD
FQANPNELTN GVINSAFMLL FKDSIRLFAA YNEGVINLLE KYFDMKKNQC KDALDIYKKF
LYRMTKLSEF LKVAEQVGID QGDIPDLSQA PSSLLEALEQ HLASLEGKKT KELNADTRAS
TLSNAVSSLS STGMSFSRMD EKEKQQALEE EQARLQALKV THFILFGQIV SGSKRALDLA
FRSVFLPARM PLLAAIPIKN AVFPYTHLTR LFTLISSSGF DALGDLLKPT VPTHTAPPPP
PPQVAIHPGG KLLANDLDSS LANLVGSEPD MQWNQPGEKK LTGGQNWQNK TMSTTQWSPA
PMAPQPMPVP HGPKVCQQNI PHSELLITEV SLIILQICCF NTRSHHVSYP Q
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