ID   A0A669E9N8_ORENI        Unreviewed;       560 AA.
AC   A0A669E9N8;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Phosphatidylinositol binding clathrin assembly protein {ECO:0000313|Ensembl:ENSONIP00000067716.1};
GN   Name=PICALM {ECO:0000313|Ensembl:ENSONIP00000067716.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000067716.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000067716.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
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DR   AlphaFoldDB; A0A669E9N8; -.
DR   Ensembl; ENSONIT00000055251.1; ENSONIP00000067716.1; ENSONIG00000004669.2.
DR   GeneTree; ENSGT00950000183068; -.
DR   Proteomes; UP000005207; Linkage group LG10.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          343..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  61507 MW;  6556960E37F6A01F CRC64;
     MSGQSITDRI TAAQHSVTGS AISKTVCKAT THEIMGPKKK HLNYLIQCTN EMNVNIPQLA
     DTLFERTTST SWVVVFKSLT TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
     STFIRRYSRY LNEKAVSYRQ VAFDFTKVER GSDGVMRTMN TEKLLKTISV IQNQMDALLD
     FNVNANELTN GVINAAFMLL FKDAIRLFAA YNEGVINLLE KYFDMKKVQC KEGLDLYKKF
     LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKV KDSTAASRAS
     TLSSAVSSLA NTGMSFSKVD EREKQAALEE EQARLKALKE QRLKELQKNP TTATTDSSPV
     SLDGTIDSAP VLDPFSTTNS TSSSSCTPVR GWAEGETVTV LGQFGPSILS LLYFDVLGGI
     LKPTVASSPH QSMTLNSQQP HPKLVSDDLD SSLANLVGNL GIGNGRAKND LHWNQSDEKK
     LTGGTNWLPN TAPSTTWNPA TMAPSAVAFP AATPTGMMAY AMPPRMGSMM ITQPTMMYTQ
     PVMRSPNPFG PSPGAQMQFM
//