ID A0A669F4A7_ORENI Unreviewed; 1228 AA.
AC A0A669F4A7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSONIP00000078281.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000078281.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000078281.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A669F4A7; -.
DR Ensembl; ENSONIT00000057036.1; ENSONIP00000078281.1; ENSONIG00000008941.2.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1228
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025607941"
FT TRANSMEM 1145..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 862..922
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 107..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 137586 MW; E719CEECBB00B6BB CRC64;
MNGEVIFCPK WHRAFWFLLF AVPCFLHAGE AEITCRSCQP GSKWRGKELL LKFHTSESAT
GFRGQVFGNS ERRFGAASAE TPRLSCAVGS AECARARVEY PETSLKRNTR DLRAKGELGQ
SEFTQMKVSN VSTSGQKKNG RVEGVRRRAR RNSHGDKLGS PRSAQNQDRG EATGTVAGRR
VTRSELRWSG EERRAAGPRQ EELKLNSSTF ALTGDSSHNQ AMVHWSGQNS SVILMLTKLF
DFNLNSVTES SLWRSTDYGA TYQKLNDKVG AKTILSYLYV SPNNKRKIML LTDPEVESSL
LISSDEGATY QKYRLNFYIL SLLFHPEQED WILAYSHDQK LYSSVEFGRR WQLVHERVAP
NRFYWYVLVH DAEQFLFFTN YKALYVTCKL QNCTDANKGK PFPGYIDPNS LVVQDEYVFV
QVGNSGGRPI YYVSAKRDVF TPMKLPKYTL PKDLHVISTD ENRVVAAVRE WNQNETYNLY
VSDTSGVYYT LALENVVSSM GPEGNVMVDL YEVAGIKGMF LANKRTDNQV KTYITYNRGR
DWRLLQAPSK DLRGNSIHCV LPYCSLHLHL HVSANPYTSG NIASRDSAPG IIVASGSIGA
ELTTSNVSVF ITSDAGNTWR QIFDEEYAVL YLDQGGALVA IRHTPLPIRH LWLSFDEGRQ
WNKYSFTNTP LFVDGVLGEP GEETLIMTIF GHVSHRSEWQ LVKIDFRSIF NRRCIEADYQ
TWHLHNQGEP CLMGVKRIYR KLKPTSRCVM GKTYSVTMTS APCDCTEADF ECDYGFERRT
DGKCTPAFWF HPSSMSRSCT TGMTFLNSTG YRKVVSNNCT AGVSAEYTAR RQQCPIQAPK
GLHLVTSEGS LTAVLGTNVT FLVFLEEGDG ARTSITLDFG DGHALTYSNV SSIEDGIKHI
YKAVGIYRVT ATGENSLGSE TAMLYLHVTC QLEYIHLSAP FVAVRNKEVN LTAVLWPSQV
GTVTYIWWIG NNTEPVITLE GSVAYTFSRE GINTVTVQVS AGNTILQDRK TIAVHEYFRS
HLLAFSSNLD EHNPDIAEWR LDVSRVIKNS LIQATGVRED QLLVTVLPGL PTAAEFFLLP
DKQITEGKPE KSSAHLDQLS ELLLSALNQN LVQFTLRPGV QVTVYAAHLS AAPLVDTSEN
HSGSAMLMLL SVVVVGLAVF VIYKFKRKIP GLNVYAQMQN EKEQEMSPAN PTVATPSSQQ
DLVHSLEILD TEFNSRPIGK HPRTTKQK
//
