ID A0A669F636_ORENI Unreviewed; 1181 AA.
AC A0A669F636;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|Ensembl:ENSONIP00000078473.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSONIP00000078473.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000078473.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000078473.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_005471674.2; XM_005471617.3.
DR AlphaFoldDB; A0A669F636; -.
DR Ensembl; ENSONIT00000044304.1; ENSONIP00000078473.1; ENSONIG00000003786.2.
DR GeneID; 100706669; -.
DR GeneTree; ENSGT00940000157657; -.
DR InParanoid; A0A669F636; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..395
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 507..789
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 803..921
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 927..1181
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 82..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 130794 MW; AE2474B13D49B828 CRC64;
MGEQRGRAQP YCNQSSDRRR EWELLAVLGT CTRRVRSTNY PLCCPPLKSS TGEEKEHGGQ
ICGSPRWRWR DCPRTGAHLD AVAADPGFDT GGGSSSSTDT GQEKEPLEDS VFEPLDPGVA
VPILEYNREP NKYGDGVPKE NSPFINNTDD KGNSYDGTNM ALFEEEMDSN PMVSSFLSKL
ANYTNLSQGA QEHEEADDDE GPKKKAVKSP QMGTFMGVYL PCLQNILGVI LFLRLTWIVG
TAGILESLAI VGLCCSCTML TAISMSAIAT NGVVPAGGSY YMISRSLGPE FGGAVGLCFY
LGTTFAGSMY ILGTIEILLT YMVPKAAIFV ADKKEDELDA LLNNMRVYGT CCLALMAVVV
FVGVKYVNKL ALVFLACVIL SILAIYAGVI KTIFDPPYFP VCMLGNRTLK NHQFDKCNKT
EVIDNMTVTT QLWSLFCDGS HLNATCNEYF ASNNVTELQG IPGLTSGVIS ENMWSTYGPL
GMLVEKSNLP SLEGGDPTQD IYMPYVVNDI TTFFTLLVGI YFPSVTGIMA GSNRSGDLRD
AQKSIPIGTI LAITTTSVIY ITSVVLFGAC IEGVLLRDKY GDSVKGNLVI GTLSWPSPWV
IVIGSFFSCC GAGLQSLTGA PRLLQAIARD GIVPFLQVFG HGKANGEPTW ALLLTAGICE
IGILIASLDA VAPILSMFFL MCYLFVNLAC AVQTLLRTPN WRPRFKYYHW ALSFLGMSLC
LAIMFISSWY YAIVAMVIAG CIYKYIEYRG AEKEWGDGIR GLSLNAARYA LNRLEDAPPH
TKNWRPQLLV LLNVDSDQAV KHPRLLSFTT QLKAGKGLTI VGNVLQGTYL TKEAEAKKAE
QNIKAAMSAE RTKGFCHVVV SSNLRDGVSH LIQSAGLGGM KHNTVLMAWP GAWKQSNDPQ
SWRNFIETIR ETTAAHQALL VAKNVDSFPT NQDRLGEGTI DVWWVVHDGG LLMLLPFLLR
QHKVWRKCKM RIFTVAQMDD NSIQMKKDLQ MFLYHLRLDA EVEVVEMHDN DISAFTYEKT
LMMEQRSQML KQMHLSRTER EREAQLIHDR NTASHATIND KVDAEPEQVH MTWTKDKLLT
ERNRNRECNA NVAVRDLFNM KPEWESLNQT NVRRMHTAVK LNEVVVNKSQ GAHLVLLNMP
GPPRNRGGDE NYMEFLEVLL EGLNRVLLVR GGGREVITIY S
//
