ID A0A670IX99_PODMU Unreviewed; 431 AA.
AC A0A670IX99;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Vimentin {ECO:0000313|Ensembl:ENSPMRP00000016431.1};
GN Name=VIM {ECO:0000313|Ensembl:ENSPMRP00000016431.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000016431.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000016431.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000016431.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Vimentins are class-III intermediate filaments found in
CC various non-epithelial cells, especially mesenchymal cells. Vimentin is
CC attached to the nucleus, endoplasmic reticulum, and mitochondria,
CC either laterally or terminally. {ECO:0000256|ARBA:ARBA00002825}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A670IX99; -.
DR Ensembl; ENSPMRT00000017530.1; ENSPMRP00000016431.1; ENSPMRG00000010961.1.
DR GeneTree; ENSGT00940000156146; -.
DR Proteomes; UP000472272; Chromosome 12.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF5; VIMENTIN; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272}.
FT DOMAIN 102..378
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 265..356
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 431 AA; 49368 MW; 9438BD6AEB9BE0D8 CRC64;
MSTTSSSRSS YRRMFGGAGG RPSSSSSSRY VTSSSRYSLG SARPSSVRLV SSAPGGGGLY
ASKAVRLRGS LPPMRMLGMD GGVDFSLADA INTEFKANRT NEKAELQELN DRFANYIDKV
RFLEQQNKIL LAELEQLKGK GTSRLGDLYE EEMRELRRQV DQLTNDKARV EVDRDNLAED
IMRLREKLQD EMLQREEAEN NLQSFRQEIR ELQAQIQEQH IQIDVDVAKP DLTAALRDVR
QQYESVAAKN LQEAEEWYKS KFADLSEAAS RNNDALRQAK QEANEYRRQI QSLTCEVDAL
KGTNESLERQ MREMEENFNL EAANYQDNIA RLQDEIQNMK EEMARHLREY QELLNVKMAL
DIEIATYRKL LEGEESRITM PIPTFASLNL RETNLESIPI DTHSKRTLLI KTVETRDGQV
INETSHHDEL E
//
