ID A0A670JKF4_PODMU Unreviewed; 3483 AA.
AC A0A670JKF4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=A-kinase anchoring protein 9 {ECO:0000313|Ensembl:ENSPMRP00000025458.1};
GN Name=AKAP9 {ECO:0000313|Ensembl:ENSPMRP00000025458.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000025458.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000025458.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000025458.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR Ensembl; ENSPMRT00000027025.1; ENSPMRP00000025458.1; ENSPMRG00000013537.1.
DR GeneTree; ENSGT00730000110871; -.
DR Proteomes; UP000472272; Chromosome 12.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF1; A-KINASE ANCHOR PROTEIN 9; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272}.
FT DOMAIN 3280..3361
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2052..2097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 445..574
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 614..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 692..854
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1213..1269
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1451..1672
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1708..1861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1891..1973
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2006..2047
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2202..2362
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2712..2848
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2945..3028
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3175..3202
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3228..3262
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2066..2093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3483 AA; 402204 MW; C933E0C7F26330F1 CRC64;
APKKQKKKKK VSNTKDEESV QEGLDIDQSQ GEDASPHSCQ RGAAAASDFA IVRTLHSDEL
IKHDQIYTTE VSVFVNGCSF LTRTEVPADS IREEEFGFGE NYSELGIQHS IARLEMMENE
LAGKQQEIEE LNRELEEMRA AYGTEGLQQL QEFEAAIKKR DDIITQLTAN LQQARKEKDE
TMREFLELTE QSQKLQIQFQ HLQASEALRN TSHSSTAADL LQAKQQILAY QQQLEEQEQL
LKNYQVKNED FELQVSLLQQ REKCKTEEDF TKRKLREKET AIEELEAKIL EEEENIFILQ
KKLSAAEKSL EEVKEEILQK NQEIQNVRVE LSSSKQKERQ CSDEVKQLMG TVEELQKRYH
KDSQHDNDTV ERMELEAQRR LADLRAELEE VHGQQIVQMK QELVREHTME IEKLLAQQKA
DMERTLSLHS GNTNEDQIHL MNIAINELNL MLQEATYQKE KVRQDLSQQL EILSSEKSAL
QNKVEDLCQE LDFAREQIQR AKQTINERES KLHEVDQLQI TTAELKAQLA AASEIREQLE
EKHEAEVTNY KIKLEMLERE KDAVLGRMAE SQEAELERLR THLLFSHEEE LSKLRDDLQQ
EHRINTENLK DNMIMQSKQQ LDDLQNEMSK KMEAMQFENE NLIAKQNELT LEIARLKDLQ
ESIVNSKSEE MMLQIQDLQK EIEVLRLGEK EKGTLEQEVQ VLQLKTELLE KQMKEREDSL
QEKCRLLETQ NNFLEDKSNA LKEKLKKYAI KNTEESFTDG ISSESEEFDL QNRIDNLIAE
NEKLVKQDIE LKEEIERLQN SFSFAEQNYQ ELQKTHASLL KGKLDLEESK DKREAEYEAK
LRALTEEIQH LQGDTSVVLK SQSTIVCGKR EKILRSETFD VEEVVEKDTT ELMEKLEVTQ
REKLELSLRL SDLSEQLKLK SSQICQLNEE VRSLKEDKEH MSVKCKELEV LVSHRLEENM
NSCEHETKYP NGGLQTGHPR VCEHTGFVPD SYKDYDKAIR EEKLIANQTG GSSCLNHLQS
ESDDLKLQME AQRICLSLVY SAHVDQVREC MENEKENALS ALKEELQSHH AQELNELMKN
QLDLQNVKNQ NLGKVVKRRK IQLLFMICSY IDLKVRSPCW EDMDNFKTRL EEQHAQEVKR
LRSYFHQQLK ETEERYTAEI VHLQSRLQDA SVVHLCKIKN LLHGTHAIFN TCQQKLQIQN
EVSTSSIVSS SQRSLYEERL EDMRQELVRQ HQEHQQATEI LKQGHMKQME LQKENQEILL
AELDRLKVQL AESDTLDSES IITEREQMLL EELEALKEQL LPGREKLPCE LKTSVRFLFS
VSRCALQKAN NRLLKILLEV VKTTVAVEET IGRHVVGLLD RSSKCQLPFK SLAWETRAED
STKPSICVAY EAGTCNEASS SYHGSDVEGD GPSMWSEVTD EGLELSQYLT EHGFAGVEVD
PKNEELVLNI SSRLQAAVEK LLETINETTN QLEHAKVTQT ELMRESFKQE QEATELLRCQ
EELQERLDGE VKAREQLALE LSKAENLIDG YADEKSLLEE QIQEKTDAID HLEQELLCTG
NKLQELEAER QQLQEEKELL FRQKDAMKAD AGPVEQQLLA ETEKLMKEKI EVQRQAEKEY
DYLQKQVKAL ETDIEEQVSR YLELEHEKNA ELMDLRQQNQ ALEKQLEKTK KFLDEQAIDR
EHERDVFQQE IVKLEHQLKI PQRFQPVNEH QNREVEQLTN HLKEKTDKCS ELLLSKEQLQ
RDVQERNEEI EKLECRIREL EQALMISADS LQKVEERKQF GSTTIRGELP LEAQLQAEQE
AVDRKEKEII NLEEQLEQFR EELENKNEEV QQLHMQLEIQ HKESTTRQQE LEQENKFFKE
DMEKMGLAIQ KPEDTSIKGH HAVAGKFVQI IQEKEQEINE LHEQISKLQQ QLEITTDNKV
IEGKNEHIRE LEAQIEYLKS DQERVKQNSE QELEQLNDVI EKLQQELANI EHKVPLDFSL
TQEDADNLKY QLDVVLAEKE ALVKQVENKD VEVSVMKNEL EETKLKMGKL EKEVDAFKKE
HEKKEGIHRN MQMDSGVAEI RGSSQLKTES QKKTKMLKNE TPLGYEEENA KDSSSTKLQQ
LQEALEEKDS ELKQHCNQLT ALKEQAQAES AVLKQKITEL EETLEQKVAA ALVSQAQLKA
VLEQSKLLQE IQVVSGDALE AIKTISAEKG NSTPGEDAGS ILSSLSNKLL EMESQLAGAQ
SSLELEKAKV EIAQKEAKEK EERLAELHQL LAEVEEKHKK EKAKSSKQEK TLTVAKELSE
NKERNILSDD PELEKIRAES VAAKEELNSY REKAEKLNEQ LMVKETSLLR LEEDLRQTKD
KLAEAEEKIE NYVRKEKCIE KSEGVCINRS DASCQTDKAL HINSCNQTSQ LLVKNEEIQI
DLQNGCSAEE VAEIIKEFSE KIDKMQELHA AEIMDMETRH ISESDALKRE QFIVVQELTE
ECNTLKDVIE ALRDKEVSML ICPNDLPVLD SGSDWSQGAY LVPSQGSDAV SEGIGDEGEE
STDILPKGIK GLLRAIHREG EQIISLSESP YKESNVHSLK QGPEFWLEER KAFLGTVSSL
KDVIAKMQIH RDTEFYAGSE SSEGVSDWRA ELLYAVQQLF QKEKDVLLAA FQMELAEMGI
RDVMEIVDQL EKRLQEQVRL TYRTAVDCIQ NADRRSLLME INLLRAQLNN RRTDLRGELE
MEPKCHELLG YNMEVQMELS NIKDKAAEVQ EQLNSERVMV AELKNELGQT KLELETTLKA
QHKHLRDLEA IRNELKGKAA ELDLLKDTMA SEQKKSRELQ WALEKERAKI ERSEERGKEE
LEDLKYSLEN EKQKVAELSN LLELERELST DLQKKIQSQE TLNAAQLSQE RSCNSELQVL
LESERFRVLE INSALEREKE FCAQLQAADQ KSQDGTLTPA EELLQDLQKQ LDEKHDCIVA
LVSETEKYKL EVVQLKQQME KERQVQRKAL QTEQDANILA QKKVHELESK VEDLQWQLGE
KRQQVHQLQC EEKKLQETIQ ELQQREQREE PGVKVEKAVC QNLNETTMDT SNERTRKWVF
QQKIGGVETK ELSYSALVGI GDATKESQDL QMIGQKLISV SSTLKHLANK AAQRLPFEKA
DDEGFVGIQN NIEEVILQLQ MLSGLPNLEI SSDLPSSASL TERLLKQNAE LTGFVSRLSE
EKNNLRNAVM KLEEELRRYQ QRGACGDSTF RLSLNNGGSV DTLLASEREL WNKERLILQQ
SLKQAEAELA KLRAELRNEA FLRELGSDSE NAALKRIYGR YLRAESFRKA LIYQKKYLLL
LLGGFQECED ATLSLLARMG GQPSYTDLEV ITRRSKSFTR FRSAVRVLIA ISRMKFLVRR
WHRVTGYSLT GINRDGFSQN TGNDLRPDSF PGGLELFGEH RHSSYRSRSE LESLRSPLSY
QHRYQGIHTD LSPVSLACSQ LQNYDPDRAL TDYINRLEAL QRRLGSVQSA PASYTQLHSG
IRR
//
