ID A0A670JW33_PODMU Unreviewed; 897 AA.
AC A0A670JW33;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Solute carrier family 12 member 2 {ECO:0000313|Ensembl:ENSPMRP00000026992.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSPMRP00000026992.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000026992.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000026992.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000026992.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A670JW33; -.
DR Ensembl; ENSPMRT00000028635.1; ENSPMRP00000026992.1; ENSPMRG00000016289.1.
DR GeneTree; ENSGT00940000155742; -.
DR Proteomes; UP000472272; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..537
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 546..680
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 688..897
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 897 AA; 99466 MW; FC2ED6A3C961DE68 CRC64;
RPTIWWPREE TPTTATDPGL EELKIINCHK ACLVCCLVRC MLNIWGVMLF IRLSWIVGQA
GIGLAVLVIA MATVVTTITG LSTSAIATNG FVRGGGAYYL ISRSLGPEFG GAIGLIFAFA
NAVAVAMYVV GFAETVVELL KEHNLIMLDQ MNDIRIIGAI TIVVLLGISV AGMEWEAKAQ
IVLLVILLVA IVDFIIGTFI PFESKKSKGF FGYQGEIFYE NFGPDFREEE TFFSVFAIFF
PAATGILAGA NISGDLADPQ LAIPKGTLLA ILITTVVYMG IAVSVGACVV RDATGSINDT
FVGELTNCTT AACKLNFDFS SCEKGGCPYG LMNNFQVMSM VSGFAPLISA GIFSATLSSA
LASLVSAPKI FQALCKDNIY PGFLMFAKGY GKNNEPLRGY LLTFLIALGF ILIAELNVIA
PIISNFFLAS YALINFSVFH ASLAKSPGWR PAFKYYNMWV SLVGAILCCI VMFVINWWAA
LLTYVIVLGL YIYVTYKKPD VNWGSSTQAL TYLNALQHAV RLTGVEDHVK NFRPQCLVMS
GAPSSRPALL HLVHAFTKNV GLMICGHIHM GPRRQAMKEL STDLPRYQRW LIKNKMKAFY
APVHAEDLRD GAQYLMQAAG LGRMKPNTLV LGFKKDWQSA DMNDVDTYIN LLHDAFDFQY
GVVVIRLREG LDISHLQGQD PKGPALNMAD QKLLDASSQF QKKQGKNNID VWWLFDDGGL
TLLIPYLLTT KKKWKDCRIR VFIGGKINRI DHDRRAMATL LSKFRIDFSD IMVLGDINTK
PKKENIAAFE EMIEPFRLHE DDKEQDVADK MKEDEPWRIT DNEIELYKTK SQRQIRLNEL
LKEHSSTANL IVMSLPVARK SAVSSALYMA WIEALSKDLP PILLVRGNHQ SVLTFYS
//
