ID A0A670KGP1_PODMU Unreviewed; 1142 AA.
AC A0A670KGP1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSPMRP00000036588.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSPMRP00000036588.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000036588.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000036588.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000036588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A670KGP1; -.
DR Ensembl; ENSPMRT00000038757.1; ENSPMRP00000036588.1; ENSPMRG00000023307.1.
DR GeneTree; ENSGT00940000158030; -.
DR OMA; FRIKFAE; -.
DR Proteomes; UP000472272; Chromosome 14.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002445; Slc12a1.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01209; NAKCLTRSPRT2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 210..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..158
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 183..248
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 255..728
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 737..1142
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 31..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..894
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 31..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 126072 MW; B4676DC32C0C2B9B CRC64;
LPINMSMNNS PNVFLDPSPN RFQVNVINES HDNSVQSQGD PDSQRYEETS FADDVSNRLR
VGYRPENREL YDNFFQNGDA SKTDGNFHPY DTHSNTYYLK TFGHNTMDAV PKIGYYRNTG
SVSGVKINRP SLMDIHEQLA KNIAVTSGSV DKFAKADGNT EEAESNKEEE TKGGFVKFGW
VKGVLVRCML NIWGVMLFIR LSWIVGQAGI GLGVIIILLA TMVTSITGLS TSAIATNGFV
RGGSNIFSGI FSGLGVVVIC LSVVVTTLTG ISMSAICTNG VVRGGGAYYL ISRSLGPEFG
GSIGLIFAFA NAVAVAMYVV GFAETVVELL KNSNAIMVDA TNDIRIIGAI TVVILLGISV
AGMEWEAKAQ VILLFILLAA IVNFFIGTVI PSNNEKRARG FFNYQASIFA ENFGPDFRGD
EGFFSVFAIF FPAATGILAG ANISGDLEDP QAAIPKGTML AILVTTIAYV GVAICAAACV
VRDATGNVND TVVSGMNCNG SSACALGYDF SSCKTQTCDY GLMNNFQVMS MVSGFGPLIT
AGIFSATLSS ALTSLVSAPK VFQALCKDNI YRALHFFAKG YGKNNEPIRG YVLTFIIAMA
FILIAELNTI APIISNFFLA SYALINFSCF HASYAKSPGW RPAFKYYNMW VSLFGAILCC
GVMFVINWWA AVITYAVELF LYIYVTYKKP DVNWGSSSQA VYYINAIDSA LELTTVDDHV
KNFRPQCIVL TGEPMARPAL LDIAHSFTKN NGLCICCEVY TGPRKLCVTE MNSGMATKQA
WLTKNKRKAF YAAVAADSFR DGVKSLLQAS GLGRMRPNTL VLGFKKDWKE ATAVEVENYM
GVVHDAFDFD FGVVVARISQ GFDISQVLLV QEELKKLEQE RQVLEATIKD SKFEEGNGGI
QRYFRRAAKL NITKTIPKKE SSISTISSMH VGEFNQRLLE ASSQFKKKQG KGTIDVWWLF
DDGGLILLIP YMLTLRKKWK DCKLRIFTGG KVTRLEEEKL MMASLLSKFR IKFADIHIIG
DINMKPNKES WKFFEEMIEP YRLHESCKDL TTAEKLKREA PWKITDAELE AVKEKSYRQV
RLNELLQEHS RAANLIVLTL PVARKGIISD YLYMAWLEIL SRNLPPVLLI RGNHKNVLTF
YS
//
