ID A0A670KMQ2_PODMU Unreviewed; 684 AA.
AC A0A670KMQ2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=ATPase phospholipid transporting 8B3 {ECO:0000313|Ensembl:ENSPMRP00000036142.1};
GN Name=ATP8B3 {ECO:0000313|Ensembl:ENSPMRP00000036142.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000036142.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000036142.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000036142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A670KMQ2; -.
DR Ensembl; ENSPMRT00000038303.1; ENSPMRP00000036142.1; ENSPMRG00000023348.1.
DR GeneTree; ENSGT00940000160463; -.
DR Proteomes; UP000472272; Chromosome 18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR032631; P-type_ATPase_N.
DR PANTHER; PTHR24092:SF78; PHOSPHOLIPID-TRANSPORTING ATPASE IK; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..97
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
SQ SEQUENCE 684 AA; 78517 MW; 9A77E290B23609C9 CRC64;
MRSTWGYLGR RLGNYGWGIN NILLLLLLLL LLLLLLFQIS LRTHIFIYLF LSFHLCVQGN
GIKTAKYNVL TFLPLNLYEQ LHRLVNIYFI FIILLQVRGF SCIWERGCPK VELWSKLMGC
VCVFCSRFPQ ADLLLLSSTE PNSLCYVETM DIDGETNLKY RQALLVTHEQ LTNDGSMAAF
DGVITCEEPN SRMHSFVGTL DWRGEKYSLD SEKVLLRGCK VRNTEACYGL VIYAGFDTKI
MKNCGKIKLK KTKLSHLMDR LVLLVRRFGL GCSSFAPQAT KVFFACSTIV GFSPRRRFEF
IYLVNSCFIN WDREMYYAPK DMPAKARSTS LNDQLGQIEY VFSDKTGTLT QNIMTFKKCC
INGVIYGKVP LGSHWDLGKS PTFLSRQASE WLEFYDQQLL ENIRRNDDPM VKEFMRLLAI
CHTVMVEEKE NQLVYQAASP DEEALVTAAR NLGYVFLSRT QDTVTISELG VERTYKVLAL
LDFNSVRKRM SIVVRDPEGH IKLYTKGADT VILERLHRDR ATEGCTVKAL DVSLHKWVET
FAAETLRTLC VAMRDVDESE FSLWSKKHHA ASVLLQNRAQ ELDKVYEEIE RDLRLLGATA
IEDKLQDGVP ETIQLLKRGD IKVWVLTGDK LQETRRRAFS VVAPAMWNAL PSDVKEINNS
LMFRRHLKAA PFREFLMFSG ILCF
//
