ID A0A671DK34_RHIFE Unreviewed; 1043 AA.
AC A0A671DK34;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|EMBL:KAF6361432.1, ECO:0000313|Ensembl:ENSRFEP00010001142.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSRFEP00010001142.1};
GN ORFNames=mRhiFer1_005013 {ECO:0000313|EMBL:KAF6361432.1};
OS Rhinolophus ferrumequinum (Greater horseshoe bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC Rhinolophinae; Rhinolophus.
OX NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010001142.1, ECO:0000313|Proteomes:UP000472240};
RN [1] {ECO:0000313|Ensembl:ENSRFEP00010001142.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT "The Genome 10K Project: a way forward.";
RL Annu Rev Anim Biosci 3:57-111(2015).
RN [2] {ECO:0000313|Ensembl:ENSRFEP00010001142.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA Myers E.;
RT "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT Genomes for All Living Bat Species.";
RL Annu Rev Anim Biosci 6:23-46(2018).
RN [3] {ECO:0000313|Ensembl:ENSRFEP00010001142.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA Mountcastle J., Jarvis E.D.;
RT "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAF6361432.1, ECO:0000313|Proteomes:UP000585614}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRhiFer1 {ECO:0000313|EMBL:KAF6361432.1};
RC TISSUE=Lung {ECO:0000313|EMBL:KAF6361432.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
RN [5] {ECO:0000313|Ensembl:ENSRFEP00010001142.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; JACAGC010000006; KAF6361432.1; -; Genomic_DNA.
DR Ensembl; ENSRFET00010001272.1; ENSRFEP00010001142.1; ENSRFEG00010000873.1.
DR GeneTree; ENSGT00940000158642; -.
DR OMA; HKHMPED; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000472240; Chromosome 8.
DR Proteomes; UP000585614; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472240}.
FT DOMAIN 49..329
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 540..731
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 760..857
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 934..1031
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 451..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 645..672
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 478..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 118230 MW; 47CAF11567BC7279 CRC64;
MGEIEGTYRV LQTPGSRLGA QTAEGVSTLE PGQAPAAAAG PPGRMQTHLH LRVKLLDDTV
EVFAIEPKSD GQVLLTQVWK RLNLMEYDYF GLEFQNVPSS WVWLEPMKPI IRQVRRPKNA
MLRLAVKFFP PDPGQLQEEY TRYLFALQLK RDLLEERLSC TDTTAALLTS HLLQSEIGDY
DEAQDREHLR VHTYLPHQER SLEKILEFHR KHTGQTPAES DFQVLEVARK LEMYGIRFHK
ASDREGAKIN LAVSHMGVLV FQSTTKINTF NWSRVRKLSF KRKRFLIKLH PEVHGPYQDT
LEFLLGSRDE CKNFWKICVE YHTFFRLFDQ PKPKAKAVFF SRGSSFRYSG RTQKQLVDCV
KVGGMKRTPY ERRQSKTRMT VRTLTADLPK QSISFTEGMR TFSSPSSANT SFCSVPASPL
TPPGLPDYKD SSSSVMGPQA PHVKRLAAER NSGELEGPDA TQAPAPGHPA LRPCQGFSMD
SPQPSPSTRK SPLSLSPAFQ VTLGPAEQGS SPLLSPVLSD AGGAKMDNEE PKHKCVGADE
AYFIAKEILA TERTYLKDLE VITVWFRSAV VKEDAMPADL MTLLFSNIDP IYEFHRGFLR
EVEQRLALWE GPSSTHAAGS HQRIGDVLLR NMHHLKQFTS YFQRHDEVLT ELEKATKRFK
KLETVYREFE LQKVCYLPLN TFLLKPVQRL VQYRLLLSRL CGHYAPGHRD YADCHDALKV
ITEVTSTLQH SLVRLENLQK LTELQRDLVG IENLIAPGRE FIREGCLHKL TKKGLQQRMF
FLFSDMLLYT SRGVSGTSHF RIRGLLPLHG MLVEESENEW SVPHCFTICA AQKTIVVAAS
TRLEKEKWMH DLNTAIAAAK GSGDMTLALP GCTVCAPPRR SSDEVSVEQE SEEDARGAHS
SLEVQGQHRA NTTVHVCWYR NTSVSRADHS AAVKNQLSGY LLRKFKNSNG WQKLWVVFTN
FCLFFYKTHQ DDYPLASLPL LGYSVSVPGE ADGIHKEHVF KLQFRSHVYF FRAESKYTCG
RWMEVIERAS SSPGRAGPPE EEA
//
