ID A0A671DUG9_RHIFE Unreviewed; 1047 AA.
AC A0A671DUG9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=KIAA0319 like {ECO:0000313|Ensembl:ENSRFEP00010001869.1};
GN Name=KIAA0319L {ECO:0000313|Ensembl:ENSRFEP00010001869.1};
GN ORFNames=mRhiFer1_007292 {ECO:0000313|EMBL:KAF6344766.1};
OS Rhinolophus ferrumequinum (Greater horseshoe bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC Rhinolophinae; Rhinolophus.
OX NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010001869.1, ECO:0000313|Proteomes:UP000472240};
RN [1] {ECO:0000313|Ensembl:ENSRFEP00010001869.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT "The Genome 10K Project: a way forward.";
RL Annu Rev Anim Biosci 3:57-111(2015).
RN [2] {ECO:0000313|Ensembl:ENSRFEP00010001869.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA Myers E.;
RT "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT Genomes for All Living Bat Species.";
RL Annu Rev Anim Biosci 6:23-46(2018).
RN [3] {ECO:0000313|Ensembl:ENSRFEP00010001869.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA Mountcastle J., Jarvis E.D.;
RT "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAF6344766.1, ECO:0000313|Proteomes:UP000585614}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRhiFer1 {ECO:0000313|EMBL:KAF6344766.1};
RC TISSUE=Lung {ECO:0000313|EMBL:KAF6344766.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
RN [5] {ECO:0000313|Ensembl:ENSRFEP00010001869.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; JACAGC010000009; KAF6344766.1; -; Genomic_DNA.
DR Ensembl; ENSRFET00010002071.1; ENSRFEP00010001869.1; ENSRFEG00010001380.1.
DR GeneTree; ENSGT00940000157613; -.
DR OMA; AYVIPDE; -.
DR OrthoDB; 3021035at2759; -.
DR Proteomes; UP000472240; Chromosome 9.
DR Proteomes; UP000585614; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029865; KIAA0319-like.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46182:SF3; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319-LIKE PROTEIN; 1.
DR PANTHER; PTHR46182; FI19480P1; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00089; PKD; 5.
DR SUPFAM; SSF49299; PKD domain; 4.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 928..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..127
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 521..590
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 1020..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1047 AA; 115941 MW; 642F79DEBDA1683B CRC64;
MEKRLGVKPS PASWILSGFC WQISVKWLRN LYLFYTCFCF SALWLSTDAS ESRCQQVKTQ
FGVGLRSGGE NHLRLLEGIP SVQSCWVACC QDSACHVLWW LEGMCIQADC SRPHSCRAFR
TDSSNSMLVF FKDFQTADDL GFPPEDDVPH ILGLGWSRAS WRRQRPPRAP LTPAVSSSDQ
QSLIRKLQRR ESPIEEVPPI ETQRSEVNDS KEVGDLNTNG SEEVHKAVTV SSPLTGEIPV
WSKNVLVQPE TSEDLGTTTS AQHVKSPEKI EIATEPLPVA PSYSYATPTP QASFQSTSAP
HPVIKELVVS AGESVQITLP KNEVQLNAYV LQEPLEGETY TYDWQLITHP TDYSGEMEGK
HSQILKLSKL TPGLYEFRVI VDGQNTHGEG YVNVTVKPEP RKNRPPVAIV SPQFQEVSLP
TTSTIIDGSQ STDDDKIVQY HWEELKGPLR EEKISEDTAI LKLSKLVPGN YTFSLTVVDS
DGATNSTTAS LTVNKAVDYP PVANAGPNQV ITLPQNSITL FGNQSTDDHG ITSYEWSLSP
SSKGKVVEMQ GVRTPTLQLS AMQEGDYTYQ LTVTDTIGQQ ATAQVTVIVQ PENNKPPQAD
AGPDKELTLP VDSTTLDGSK SSDDQKIISY LWEKTQGPDG VQLENANSSV ATVTGLQVGS
YVFTLTVKDE RDLQSQSSVN VIVKEEMNKP PVAKITGNVV ITLPTDTAQL DGSKSSDDKG
IVSYLWTRDE GSPAAGEVLN HSDHHPVLFL SNLVEGTYTF HLKVTDAKGE SDTDRTTVEV
KPDPRKNNLV EIILDVNVSQ LTERLKGMFI RQIGVLLGVL DSDIIVQKIQ PYTEQSTKMV
FFVQNEPPHQ IFKGHEVAAM LKSELQKQKE HFLIFRALEV NTVTCQLNCS EHGHCDSFTK
RCICDPFWME NFIKVQLRDG DSNCEWSVLY VIIASFVIVV ALGILSWTVT CCCKRQKGKP
KRKSKYKILD ATDQESLELK PTSRAGIKQK GPMLSSSLMH SESELDSDDA IFTWPDREKG
KLLHGQNGSV PNGQTPLKAR SSREELL
//
