ID A0A671FHY1_RHIFE Unreviewed; 1221 AA.
AC A0A671FHY1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 3 {ECO:0000313|EMBL:KAF6317921.1, ECO:0000313|Ensembl:ENSRFEP00010022053.1};
GN Name=SORCS3 {ECO:0000313|Ensembl:ENSRFEP00010022053.1};
GN ORFNames=mRhiFer1_015932 {ECO:0000313|EMBL:KAF6317921.1};
OS Rhinolophus ferrumequinum (Greater horseshoe bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC Rhinolophinae; Rhinolophus.
OX NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010022053.1, ECO:0000313|Proteomes:UP000472240};
RN [1] {ECO:0000313|Ensembl:ENSRFEP00010022053.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT "The Genome 10K Project: a way forward.";
RL Annu Rev Anim Biosci 3:57-111(2015).
RN [2] {ECO:0000313|Ensembl:ENSRFEP00010022053.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA Myers E.;
RT "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT Genomes for All Living Bat Species.";
RL Annu Rev Anim Biosci 6:23-46(2018).
RN [3] {ECO:0000313|Ensembl:ENSRFEP00010022053.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA Mountcastle J., Jarvis E.D.;
RT "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAF6317921.1, ECO:0000313|Proteomes:UP000585614}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRhiFer1 {ECO:0000313|EMBL:KAF6317921.1};
RC TISSUE=Lung {ECO:0000313|EMBL:KAF6317921.1};
RX PubMed=32699395;
RA Jebb D., Huang Z., Pippel M., Hughes G.M., Lavrichenko K., Devanna P.,
RA Winkler S., Jermiin L.S., Skirmuntt E.C., Katzourakis A., Burkitt-Gray L.,
RA Ray D.A., Sullivan K.A.M., Roscito J.G., Kirilenko B.M., Davalos L.M.,
RA Corthals A.P., Power M.L., Jones G., Ransome R.D., Dechmann D.K.N.,
RA Locatelli A.G., Puechmaille S.J., Fedrigo O., Jarvis E.D., Hiller M.,
RA Vernes S.C., Myers E.W., Teeling E.C.;
RT "Six reference-quality genomes reveal evolution of bat adaptations.";
RL Nature 583:578-584(2020).
RN [5] {ECO:0000313|Ensembl:ENSRFEP00010022053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR EMBL; JACAGC010000015; KAF6317921.1; -; Genomic_DNA.
DR Ensembl; ENSRFET00010023997.1; ENSRFEP00010022053.1; ENSRFEG00010014389.1.
DR GeneTree; ENSGT01030000234563; -.
DR OMA; RRNDGNC; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000472240; Chromosome 16.
DR Proteomes; UP000585614; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KAF6317921.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000472240};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1221
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040605462"
FT TRANSMEM 1125..1143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 859..903
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 79..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1221 AA; 135737 MW; 153E3ED3169DDA1E CRC64;
MEVARTERPA GWPGAPLART GLLLLSTWVL AGAEITWGAT GGPEGPAAPV SRPVLLPLLP
RAMASQWPEE LATARRGAAL GRRPGPEPLP QPGGGSGGKK QGEDGGPSLA GARWGQGIPD
PGKPGHVRRS RRAQPPSALE RWDTRATALA DGSKESRPLA KGLREEGKAL RAGGAAAEEL
RLPSTSFALT GDSAHNQAMV HWSGHNSSVI LILTKLYDFN LGSVTESSLW RSTNYGTTYE
KLNDKVGLKT VLSYLYVNPT NKRKIMLLSD PEMESSILIS SDEGATYQKY RLTFYIQSLL
FHPRQEDWVL AYSLDQKLYS SMDFGRRWQV MHERITPNRF YWSVAGLDKE PDLVHMEART
ADGYAHYLTC RIQECAETTR SGPFARSIDI SSLVVQDEYI FIQVTTGGRA SYYVSYRREA
FAQIKLPKYS LPKDMHIIST DENQVFAAVQ EWNQNDTYNL YISDTRGIYF TLAMENIKSS
RGLMGNIIIE LYEVAGIKGI FLANKKVDDQ VKTYITYNKG RDWRLLQAPD VDLRGSPIHC
LLPFCSLHLH LQISENPYSS GRISSKATAP GLVVATGNIG PELSYTDIGV FISSDGGNTW
RQIFDEEYNV WFLDWGGALV AMKHTPLPIR HLWVSFDEGH SWDKYGFTSV PLFVDGALVE
AGMETQIMTV FGHFSLRSEW QLVKVDYKSI FSRHCTKEDY QTWHLLNQGE PCVMGERKIF
KKRKPGAQCA LGRDASGTVV SEPCVCADWD FECDYGYERH GESQCVPAFW YNPATPAKDC
SLGQSYLNST GYRRIVSNNC TDGLREKYTA KAQMCPGKAP RGLHVVTTDG RLVAEQGHNA
TFIILMEEGD LQRTNIQLDF GDGIAVSYAN FSPIEDGIKH VYRSAGIFQV TAYAENNLGS
DTAVLFLHVL CPVEHVHLRV PFVAIRNEEV NISAVVWPSQ LGTLTYFWWF GNSTKPLITL
DSSISFTFLA EGTNTITVQV AAGNALIQDT KDIAVHEYFQ SQLLSFSPNL DYHNPDIPEW
RQDIGNVIKR ALVKVTSVPE DQILVAVFPG LPTSAELFIL PPKNVTERRK GNDGDLEQIV
EILFNALNQN LVQFELKPGV QIIVYVTQLT LAPLVDSSAG RSSSAMLMLL SVVFVGLAVF
LIYKFKRKIP WINIYAQVQH DKEQEMIGSV SQSENTPKIT LSDFTEPEEL LDKELDTRVI
GGIATIANSE STKEIPNCTS V
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