GenomeNet

Database: UniProt
Entry: A0A671FQU6_RHIFE
LinkDB: A0A671FQU6_RHIFE
Original site: A0A671FQU6_RHIFE 
ID   A0A671FQU6_RHIFE        Unreviewed;      2833 AA.
AC   A0A671FQU6;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSRFEP00010026079.1};
GN   Name=NF1 {ECO:0000313|Ensembl:ENSRFEP00010026079.1};
OS   Rhinolophus ferrumequinum (Greater horseshoe bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC   Rhinolophinae; Rhinolophus.
OX   NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240};
RN   [1] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA   Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA   Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA   Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA   Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA   Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA   Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA   Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA   Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT   "The Genome 10K Project: a way forward.";
RL   Annu Rev Anim Biosci 3:57-111(2015).
RN   [2] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA   Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA   Myers E.;
RT   "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT   Genomes for All Living Bat Species.";
RL   Annu Rev Anim Biosci 6:23-46(2018).
RN   [3] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA   Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA   Mountcastle J., Jarvis E.D.;
RT   "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRFEP00010026079.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   Ensembl; ENSRFET00010028341.1; ENSRFEP00010026079.1; ENSRFEG00010017372.1.
DR   GeneTree; ENSGT00550000074797; -.
DR   Proteomes; UP000472240; Chromosome 21.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd13313; PH_NF1; 1.
DR   CDD; cd05130; RasGAP_Neurofibromin; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472240}.
FT   DOMAIN          1236..1452
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          1581..1739
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   REGION          2785..2833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2803..2833
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2833 AA;  318530 MW;  1509E58999599D31 CRC64;
     MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTT
     ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
     LHTCREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NVDVHDIELL
     QYINVDCAKL KRLLKETAFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT
     DMAECAEKLF DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ENNMNKKLFL
     DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP
     SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN
     SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK
     PTDLETRSYK YLLLSMVKLI HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSHMPE
     IAQEAMEALL VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL
     REILICRNKF LLKNKADRSS CHFLFVYGVG CDVSSGGNTS QMSMDHEELL RTCTPGASLR
     KGKGNSSVDS AAGCSGTPPI CRQAQTKLEV ALYMFLWSPD TEAVLVAMSC FRHLCEEADI
     RCGVDEVSVH NFLPNYNTFM EFASVSNMMS TGRAALQKRV MALLRRIEHP TAGNTEAWED
     THAKWEQATK LILNYPKAKM EDGQAAESLH KTIVKRRMSH VSGGGSIDLS DTDSLQEWIN
     MTGFLCALGG VCLQQRSNSG LATYSPPMGP VSERKGSMIS VMSSEGNADT PVSKFMDRLL
     SLMVCNHEKV GLQIRTNVKD LLGLELSPAL YPMLFNKLKN TISKFFDSQG QVLLTDTNTQ
     FVEQTIAIMK NLLDNHTEGS SEHLGQASIE TMMLNLVRYV RVLGNMVHAI QIKTKLCQLV
     EVMMARRDDL SFCQEMKFRN KMVEYLTDWV MGTSNQAADD DVKCLTRDLD QASMEAVVSL
     LAGLPLQPEE GDGVELMEAK SQLFLKYFTL FMNLLNDCSE VEDENAQTGG RKRGMSRRLA
     SLRHCTVLAM SNLLNANVDS GLMHSIGLGY HKDLQTRATF MEVLTKILQQ GTEFDTLAET
     VLADRFERLV ELVTMMGDQG ELPIAMALAN VVPCSQWDEL ARVLVTLFDS RHLLYQLLWN
     MFSKEVELAD SMQTLFRGNS LASKIMTFCF KVYGATYLQK LLDPLLRIVI TSSDWQHVSF
     EVDPTRLEQS ESLEDNQRNL LQMTEKFFHA IISSSSEFPP QLRSVCHCLY QATCHSLLNK
     ATVKEKKENK KSVVSQRFPQ NSIGAVGSAM FLRFINPAIV SPYEAGILDK KPPPRIERGL
     KLMSKILQSI ANHVLFTKEE HMRPFNDFVK SNFDAARRFF LDIASDCPTS DAVNHSLSFI
     SDGNVLALHR LLWNNQEKIG QYLSSNRDHK AVGRRPFDKM ATLLAYLGPP EHKPVADTHW
     SSLNLTSSKF EEFMTRHQVH EKEEFKALKT LSIFYQAGTS KAGNPIFYYV ARRFKTGQIN
     GDLLIYHVLL TLKPYYAKPY EIVVDLTHTG PSNRFKTDFL SKWFVVFPGF AYDNVSAVYI
     YNCNSWVREY TKYHERLLTG LKGSKRLIFI DCPGKLAEHI EHEQQKLPAA TLALEEDLKV
     FHNALKLAHK DTKVSIKVGS TAVQVTSAER TKVLGQSVFL NDIYYASEIE EICLVDENQF
     TLTIANQGTP LTFMHQECDA IVQSIIHIRT RWELSQPDSI PQHTKIRPKD VPGTLLNIAL
     LNLGSSDPSL RSAAYNLLCA LTCTFNLKIE GQLLETSGLC IPANNTLFIV SISKTLAANE
     PHLTLEFLEE CISGFSKSSI ELKHLCLEYM TPWLSNLVRF CKHNDDAKRQ RVTAILDKLI
     TMTINEKQMY PSIQAKIWGS LGQITDLLDV VLDSFIKTSA TGGLGSIKAE VMADTAVALA
     SGNVKLVSSK VIGRMCKIID KTCLSPTPTL EQHLMWDDIA ILARYMLMLS FNNSLDVAAH
     LPYLFHIVTF LVATGPLSLR ASTHGLVINI IHSLCTCSQL HFSEETKQVL RLSLTEFSLP
     KFYLLFGISK VKSAAVIAFR SSYRDRSFSP GSYERETFAL TSLETVTEAL LEIMEACMRD
     IPTCKWLDQW TELAQRFAFQ YNPSLQPRAL VVFGCISKRV SHGQIKQIIR ILSKALESCL
     KGPDTYNSQV LIEATVIALT KLQPLLNKDS PLHKALFWVA VAVLQLDEVN LYSAGTALLE
     QNLHTLDSLR IFNDKSPEEV FMAIRNPLEW HCKQMDHFVG LNFNSNFNFA LVGHLLKGYR
     HPSPAIVART VRILHTLLTL VNKHRNCDKF EVNTQSVAYL AALLTVSEEV RSRCSLKHRK
     SLLLTDISME NVPMDTYPIH HGDPSYRTLK ENQPWSSPKG SEGYLAASYP AVGQTSPRAR
     KSMSLDMGQP SQANTKKLLG TRKSFDHLIS DTKAPKRQEM ESGITTPPKM RRVAETDYEM
     ETQRISSSQQ HPHLRKVSVS ESNVLLDEEV LTDPKIQALL LTVLATLVKY TTDEFDQRIL
     YEYLAEASVV FPKVFPVVHN LLDSKINTLL SSCQDPNLLN PIHGIVQSVV YHEESPPQYQ
     TSYLQSFGFN GLWRFAGPFS KQTQIPDYAE LIVKFLDALI DTYLPGIDEE TSEESLLTPT
     SPYPPAVQSQ LSITANLNLS NSMTSLATSQ HSPGIDKENV ELSPTTGHCN SGRTRHGSAS
     QVQKQRSAGS FKL
//
DBGET integrated database retrieval system