ID A0A671FQU6_RHIFE Unreviewed; 2833 AA.
AC A0A671FQU6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSRFEP00010026079.1};
GN Name=NF1 {ECO:0000313|Ensembl:ENSRFEP00010026079.1};
OS Rhinolophus ferrumequinum (Greater horseshoe bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Rhinolophidae;
OC Rhinolophinae; Rhinolophus.
OX NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240};
RN [1] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT "The Genome 10K Project: a way forward.";
RL Annu Rev Anim Biosci 3:57-111(2015).
RN [2] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA Myers E.;
RT "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT Genomes for All Living Bat Species.";
RL Annu Rev Anim Biosci 6:23-46(2018).
RN [3] {ECO:0000313|Ensembl:ENSRFEP00010026079.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA Mountcastle J., Jarvis E.D.;
RT "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSRFEP00010026079.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSRFET00010028341.1; ENSRFEP00010026079.1; ENSRFEG00010017372.1.
DR GeneTree; ENSGT00550000074797; -.
DR Proteomes; UP000472240; Chromosome 21.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472240}.
FT DOMAIN 1236..1452
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1581..1739
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2785..2833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2833 AA; 318530 MW; 1509E58999599D31 CRC64;
MAAHRPVEWV QAVVSRFDEQ LPIKTGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTT
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
LHTCREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NVDVHDIELL
QYINVDCAKL KRLLKETAFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQIPQT
DMAECAEKLF DLVDGFAEST KRKAAVWPLQ IILLILCPEI IQDISKDVVD ENNMNKKLFL
DSLRKALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP
SKPFSRGSQP ADVDLMIDCL VSCFRISPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN
SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHPAI RMAPSLTFKE KVTSLKFKEK
PTDLETRSYK YLLLSMVKLI HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSHMPE
IAQEAMEALL VLHQLDSIDL WNPDAPVETF WEISSQMLFY ICKKLTSHQM LSSTEILKWL
REILICRNKF LLKNKADRSS CHFLFVYGVG CDVSSGGNTS QMSMDHEELL RTCTPGASLR
KGKGNSSVDS AAGCSGTPPI CRQAQTKLEV ALYMFLWSPD TEAVLVAMSC FRHLCEEADI
RCGVDEVSVH NFLPNYNTFM EFASVSNMMS TGRAALQKRV MALLRRIEHP TAGNTEAWED
THAKWEQATK LILNYPKAKM EDGQAAESLH KTIVKRRMSH VSGGGSIDLS DTDSLQEWIN
MTGFLCALGG VCLQQRSNSG LATYSPPMGP VSERKGSMIS VMSSEGNADT PVSKFMDRLL
SLMVCNHEKV GLQIRTNVKD LLGLELSPAL YPMLFNKLKN TISKFFDSQG QVLLTDTNTQ
FVEQTIAIMK NLLDNHTEGS SEHLGQASIE TMMLNLVRYV RVLGNMVHAI QIKTKLCQLV
EVMMARRDDL SFCQEMKFRN KMVEYLTDWV MGTSNQAADD DVKCLTRDLD QASMEAVVSL
LAGLPLQPEE GDGVELMEAK SQLFLKYFTL FMNLLNDCSE VEDENAQTGG RKRGMSRRLA
SLRHCTVLAM SNLLNANVDS GLMHSIGLGY HKDLQTRATF MEVLTKILQQ GTEFDTLAET
VLADRFERLV ELVTMMGDQG ELPIAMALAN VVPCSQWDEL ARVLVTLFDS RHLLYQLLWN
MFSKEVELAD SMQTLFRGNS LASKIMTFCF KVYGATYLQK LLDPLLRIVI TSSDWQHVSF
EVDPTRLEQS ESLEDNQRNL LQMTEKFFHA IISSSSEFPP QLRSVCHCLY QATCHSLLNK
ATVKEKKENK KSVVSQRFPQ NSIGAVGSAM FLRFINPAIV SPYEAGILDK KPPPRIERGL
KLMSKILQSI ANHVLFTKEE HMRPFNDFVK SNFDAARRFF LDIASDCPTS DAVNHSLSFI
SDGNVLALHR LLWNNQEKIG QYLSSNRDHK AVGRRPFDKM ATLLAYLGPP EHKPVADTHW
SSLNLTSSKF EEFMTRHQVH EKEEFKALKT LSIFYQAGTS KAGNPIFYYV ARRFKTGQIN
GDLLIYHVLL TLKPYYAKPY EIVVDLTHTG PSNRFKTDFL SKWFVVFPGF AYDNVSAVYI
YNCNSWVREY TKYHERLLTG LKGSKRLIFI DCPGKLAEHI EHEQQKLPAA TLALEEDLKV
FHNALKLAHK DTKVSIKVGS TAVQVTSAER TKVLGQSVFL NDIYYASEIE EICLVDENQF
TLTIANQGTP LTFMHQECDA IVQSIIHIRT RWELSQPDSI PQHTKIRPKD VPGTLLNIAL
LNLGSSDPSL RSAAYNLLCA LTCTFNLKIE GQLLETSGLC IPANNTLFIV SISKTLAANE
PHLTLEFLEE CISGFSKSSI ELKHLCLEYM TPWLSNLVRF CKHNDDAKRQ RVTAILDKLI
TMTINEKQMY PSIQAKIWGS LGQITDLLDV VLDSFIKTSA TGGLGSIKAE VMADTAVALA
SGNVKLVSSK VIGRMCKIID KTCLSPTPTL EQHLMWDDIA ILARYMLMLS FNNSLDVAAH
LPYLFHIVTF LVATGPLSLR ASTHGLVINI IHSLCTCSQL HFSEETKQVL RLSLTEFSLP
KFYLLFGISK VKSAAVIAFR SSYRDRSFSP GSYERETFAL TSLETVTEAL LEIMEACMRD
IPTCKWLDQW TELAQRFAFQ YNPSLQPRAL VVFGCISKRV SHGQIKQIIR ILSKALESCL
KGPDTYNSQV LIEATVIALT KLQPLLNKDS PLHKALFWVA VAVLQLDEVN LYSAGTALLE
QNLHTLDSLR IFNDKSPEEV FMAIRNPLEW HCKQMDHFVG LNFNSNFNFA LVGHLLKGYR
HPSPAIVART VRILHTLLTL VNKHRNCDKF EVNTQSVAYL AALLTVSEEV RSRCSLKHRK
SLLLTDISME NVPMDTYPIH HGDPSYRTLK ENQPWSSPKG SEGYLAASYP AVGQTSPRAR
KSMSLDMGQP SQANTKKLLG TRKSFDHLIS DTKAPKRQEM ESGITTPPKM RRVAETDYEM
ETQRISSSQQ HPHLRKVSVS ESNVLLDEEV LTDPKIQALL LTVLATLVKY TTDEFDQRIL
YEYLAEASVV FPKVFPVVHN LLDSKINTLL SSCQDPNLLN PIHGIVQSVV YHEESPPQYQ
TSYLQSFGFN GLWRFAGPFS KQTQIPDYAE LIVKFLDALI DTYLPGIDEE TSEESLLTPT
SPYPPAVQSQ LSITANLNLS NSMTSLATSQ HSPGIDKENV ELSPTTGHCN SGRTRHGSAS
QVQKQRSAGS FKL
//