ID A0A671TK38_SPAAU Unreviewed; 1114 AA.
AC A0A671TK38;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 5-like {ECO:0000313|Ensembl:ENSSAUP00010001207.1};
GN Name=LOC115583137 {ECO:0000313|Ensembl:ENSSAUP00010001207.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010001207.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010001207.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A671TK38; -.
DR Ensembl; ENSSAUT00010001260.1; ENSSAUP00010001207.1; ENSSAUG00010000584.1.
DR GeneTree; ENSGT00940000165387; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 232..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..275
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 389..674
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 688..806
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 819..944
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1046..1114
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 18..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 122409 MW; CA9A248F39860FBA CRC64;
DSPCASDCEL ADRCFSVDNP KESSPFINSS DAAAEKSQQY DGKNMALFEE EMDTSPMVSS
LLSSLANYSN LPQGSKEHEE AENNEERNKE SAPQLGTLMG VYLPCIQNIF GVILFLRMTW
LVGIGGVIGT FIIVFMCCAT TMLTAISMSA IATNGVVPAG GSYYMISRSL GPEFGGAVGI
CFYLGTTYAG AMYILGAIEL LLIYIAPKAA IFPLEGLEGA EAEAALLNNM RVYGTILLTS
MATVVFVGVK YVNKLALVFL ACVILSILAV YAGVIKTAVD PPVFPVCILG NRTLVWKTFD
VCAKTVETAN GTVTTQLWRM FCDSTLLNAT CDKYFTANNV TEIQGIPGVT SGILAENLFG
TYYEKGDLIA RTNMESVEDP DDPLTNSNRY VLADITSFFT LLVGIYFPSV TGIMAGSNRS
GDLRDAQKSI PIGTIAAITT TSTVYMSSVF LFGACIEGVV LRDKFGEGVH GNLVIGTLAW
PSPWVIVIGS FFSTCGAGLQ SLTGAPRLMQ AIAKDSIVPA LRIFGHGKAN GEPTWSLLLT
ACICESGILI ASLDAVAPIL SMFFLMCYMF VNLACALQTL LRTPNWRPRF KFYHWTLSFL
GMSLCLTLMF ICSWYYAIVA MVIAGSIYKY IEFAGAEKEW GDGIRGLSLS AARYALMRLE
EGPPHTKNWR PQLLVLVSTD AEQNVEQPRL LSLTNQLKAG KGLTIVGTAL EGSFLANYEQ
TQRAEQALRK LMETEKVKGF CQATVSSNLR DATSHLLQAS GLGGLKHNAV LVSWPRNWKQ
GDEHQTWRNF VELVRETTAA HLALLVPKNI AAFPSNGERF TEGHIDVWWI VHDGGMLMLL
PFLLRQHKVW RKCKMRIFTV AQMDDNSIQM KKDLTTFLYH LRIDAMVEVV EMHDSDISAY
TYEKTLVMEQ RSQMLKKINL TKTEREREIQ SITDSSRGSI RRKNPAAVTT QLSVTEDPPA
ASKEEKPEEE VQLIHDNTTP TSPATPATPL TPGEGAQSPG EQVQMTWTEK CDGEPAKPPG
AATPEGIKDI FNMKPEWENL NQSNVRRMHT ALRLNEVIIK KSSEAKLVLL NMPGPPRNRT
GDENYMEFLE VLTDGLNRVL LVRGGGREVI TIYS
//
