ID   A0A671UT18_SPAAU        Unreviewed;       903 AA.
AC   A0A671UT18;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSSAUP00010017104.1};
GN   Name=mcf2 {ECO:0000313|Ensembl:ENSSAUP00010017104.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010017104.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010017104.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A671UT18; -.
DR   Ensembl; ENSSAUT00010018100.1; ENSSAUP00010017104.1; ENSSAUG00010007653.1.
DR   GeneTree; ENSGT00940000156974; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00150; SPEC; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT   DOMAIN          1..107
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          520..700
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          718..834
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          448..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          851..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..885
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..903
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  103424 MW;  EF74969B2635417A CRC64;
     MFPIGRAGTF RPAEMASRTM GDCFYRRGIP KMRRSPASFP GNLHLVLVLR PTSFFHRTVT
     DIGFRFSQED FMLKMPVVML SSVTDLLRYI DENQLTSEFG GTLDYCHSDW IVLRTAIESF
     AVTVKDIAQM LQGFGTELAE TELPDEGKAI ESLLESHTGK YRKLKDAIRS VSKEGRHLLL
     SLETSGKEDD SQWDVKLDWE TVQRLLAQLR DMESAFDGFF EKHHLKLHQY LQLLRYEQSF
     QEMELCLDHL MAQERELTTS VDTEAQTEQA LKRLDGLESN AQEVMTRAQI IILHGHQLSA
     GHHYAMALIM QRCNELRHYC DTLNAALKTK HTRLLQTHQL LLCLGQAQTW CDDGAYLLAN
     QLVDKFQSKD GAQAALRDIE GFLDGAPSML SSGPDVLAIE YEAVITSQLQ AKIGETFEKH
     AAVQQMIQNR QASLRKLADK HVRPVQLVAP RPENPPRSKS PLFSPKHGDG LKFTFDLSLP
     GKRTSRKSPN TRKIEVIHDY QESRSCVSYS LEGEDSPDLL KRHVMRELIE TERIYVEELL
     AVLLGYRAEM DNPALSGLLP PILRSKRDIL FGNMPEIYNF HSRVFLQDLE GCLEAPEGVG
     ACFLERKESF QMYECYCQNK PRSEALWRQF SDCSFFQECQ KKLEHKLGLD SYLLKPIQRL
     TKYQLLLKEL LKYSTDCEGT SELQGALTAM LDLLKSVNDS MHQIAITGYE GEICELGRVL
     MQGSFSVWIS HKRGPTRMKE LARFKPMQRH LFLYERALLF CKKREEHGDG CDKTPSYSFK
     HCLKMTAVGI TENVKGDVKK FEIWYSGREE VYVVQAPTLE VKMAWLNELR RILTNQQKML
     RDEAYQHGQM VGHVPLSPPH SESKQQRASV SSEDTESGRS SPDPQPHSPK HQHNRRTVQV
     HFD
//