ID A0A671UT18_SPAAU Unreviewed; 903 AA.
AC A0A671UT18;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSSAUP00010017104.1};
GN Name=mcf2 {ECO:0000313|Ensembl:ENSSAUP00010017104.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010017104.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010017104.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A671UT18; -.
DR Ensembl; ENSSAUT00010018100.1; ENSSAUP00010017104.1; ENSSAUG00010007653.1.
DR GeneTree; ENSGT00940000156974; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT DOMAIN 1..107
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 520..700
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 718..834
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 448..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 103424 MW; EF74969B2635417A CRC64;
MFPIGRAGTF RPAEMASRTM GDCFYRRGIP KMRRSPASFP GNLHLVLVLR PTSFFHRTVT
DIGFRFSQED FMLKMPVVML SSVTDLLRYI DENQLTSEFG GTLDYCHSDW IVLRTAIESF
AVTVKDIAQM LQGFGTELAE TELPDEGKAI ESLLESHTGK YRKLKDAIRS VSKEGRHLLL
SLETSGKEDD SQWDVKLDWE TVQRLLAQLR DMESAFDGFF EKHHLKLHQY LQLLRYEQSF
QEMELCLDHL MAQERELTTS VDTEAQTEQA LKRLDGLESN AQEVMTRAQI IILHGHQLSA
GHHYAMALIM QRCNELRHYC DTLNAALKTK HTRLLQTHQL LLCLGQAQTW CDDGAYLLAN
QLVDKFQSKD GAQAALRDIE GFLDGAPSML SSGPDVLAIE YEAVITSQLQ AKIGETFEKH
AAVQQMIQNR QASLRKLADK HVRPVQLVAP RPENPPRSKS PLFSPKHGDG LKFTFDLSLP
GKRTSRKSPN TRKIEVIHDY QESRSCVSYS LEGEDSPDLL KRHVMRELIE TERIYVEELL
AVLLGYRAEM DNPALSGLLP PILRSKRDIL FGNMPEIYNF HSRVFLQDLE GCLEAPEGVG
ACFLERKESF QMYECYCQNK PRSEALWRQF SDCSFFQECQ KKLEHKLGLD SYLLKPIQRL
TKYQLLLKEL LKYSTDCEGT SELQGALTAM LDLLKSVNDS MHQIAITGYE GEICELGRVL
MQGSFSVWIS HKRGPTRMKE LARFKPMQRH LFLYERALLF CKKREEHGDG CDKTPSYSFK
HCLKMTAVGI TENVKGDVKK FEIWYSGREE VYVVQAPTLE VKMAWLNELR RILTNQQKML
RDEAYQHGQM VGHVPLSPPH SESKQQRASV SSEDTESGRS SPDPQPHSPK HQHNRRTVQV
HFD
//