ID A0A671VD58_SPAAU Unreviewed; 895 AA.
AC A0A671VD58;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Mcf.2 cell line derived transforming sequence-like a {ECO:0000313|Ensembl:ENSSAUP00010024305.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSSAUP00010024305.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010024305.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010024305.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A671VD58; -.
DR Ensembl; ENSSAUT00010025675.1; ENSSAUP00010024305.1; ENSSAUG00010010458.1.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT DOMAIN 1..105
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 448..628
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 646..762
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 400..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..885
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 102286 MW; 03A7BF5A401636CB CRC64;
SMSHFLRLIY GNANDFMSLS DISEHASGPA RFACVRGSFP GNLHLVLVLR PTTLLQRTLS
DFLFKFNRDE FKMKVVMLSS VTELHAYIDP GQLTTELGGT QEYCHDSWIS HRTAIEAFAL
MVKTTAQTLQ AFGTELAETE LPNDAEATTN LLHTHTLKKE KMKVGYTDPE YSMTYDELEN
LATVQRLLGQ LDETETAFDD FWERHRTKLE QCLQLRHFEH HFREVRHFST RFGSQEGTLA
RVFQQLSHRL PPPYDVLDRA LSLAGEGDML IENSHYAEDS IRPKCSELRG VCEEVSSTLR
SKKSLLLRAM ELHHALEKAS RWCEDGIFLL ASQSVDRCQS QDGAEAALQE LERYLDTASL
HTLADRNAIC CQYEVERVFQ KQSSVQEMFE KRRVSLKKLA AKQTRPVQPV APRPEVKSPL
SSPSKPRSVD GDLMRESSMY QGSSHLAGIT HVMNELLETE RAYVEELLCV LEGYAAEMDN
PAMAHLIPAT LLSKKDVLFG NMSEIYQFHK RTFLKELEAY TDCPELVGRC FLERMKDLQI
YEAYCQNKPR SESLWRQCSD CAFFQECQKK LEHKLGLDSY LLKPVQRITK YQLLLKELLK
YSKGREGCDD LQEALSSILG ILKAVNDSMH LIAITGYEGN LSELGRLLMQ GSFSVWTEHK
KGHAKVKDLA RFKPMQRHLF LHEKALLFCK RREENGEGYE KAPSYSFKHS LSMSAVGITE
NAKGDNKKFE IWCNSRDEVF IAQAPTPEIK TAWVNEIRKV LTQQLQACRG TADTPRASRA
CLHDFRSPAS NWSRLLYILD ASQQKSSDPV SPSPTSNNTS VSLRFVSRLV KHFASIRSAH
RRDACVLVQL CFLPPVPFAA AGRKTRRSRR RRRWRRARSP KSTPPRLRRN TKVNV
//