ID   A0A671VD58_SPAAU        Unreviewed;       895 AA.
AC   A0A671VD58;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Mcf.2 cell line derived transforming sequence-like a {ECO:0000313|Ensembl:ENSSAUP00010024305.1};
GN   Name=MCF2L {ECO:0000313|Ensembl:ENSSAUP00010024305.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010024305.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010024305.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A671VD58; -.
DR   Ensembl; ENSSAUT00010025675.1; ENSSAUP00010024305.1; ENSSAUG00010010458.1.
DR   GeneTree; ENSGT00940000157874; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01227; PH_Dbs; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.58.60; -; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR035534; DBS_PH.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT   DOMAIN          1..105
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          448..628
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          646..762
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          400..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          862..895
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..885
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   895 AA;  102286 MW;  03A7BF5A401636CB CRC64;
     SMSHFLRLIY GNANDFMSLS DISEHASGPA RFACVRGSFP GNLHLVLVLR PTTLLQRTLS
     DFLFKFNRDE FKMKVVMLSS VTELHAYIDP GQLTTELGGT QEYCHDSWIS HRTAIEAFAL
     MVKTTAQTLQ AFGTELAETE LPNDAEATTN LLHTHTLKKE KMKVGYTDPE YSMTYDELEN
     LATVQRLLGQ LDETETAFDD FWERHRTKLE QCLQLRHFEH HFREVRHFST RFGSQEGTLA
     RVFQQLSHRL PPPYDVLDRA LSLAGEGDML IENSHYAEDS IRPKCSELRG VCEEVSSTLR
     SKKSLLLRAM ELHHALEKAS RWCEDGIFLL ASQSVDRCQS QDGAEAALQE LERYLDTASL
     HTLADRNAIC CQYEVERVFQ KQSSVQEMFE KRRVSLKKLA AKQTRPVQPV APRPEVKSPL
     SSPSKPRSVD GDLMRESSMY QGSSHLAGIT HVMNELLETE RAYVEELLCV LEGYAAEMDN
     PAMAHLIPAT LLSKKDVLFG NMSEIYQFHK RTFLKELEAY TDCPELVGRC FLERMKDLQI
     YEAYCQNKPR SESLWRQCSD CAFFQECQKK LEHKLGLDSY LLKPVQRITK YQLLLKELLK
     YSKGREGCDD LQEALSSILG ILKAVNDSMH LIAITGYEGN LSELGRLLMQ GSFSVWTEHK
     KGHAKVKDLA RFKPMQRHLF LHEKALLFCK RREENGEGYE KAPSYSFKHS LSMSAVGITE
     NAKGDNKKFE IWCNSRDEVF IAQAPTPEIK TAWVNEIRKV LTQQLQACRG TADTPRASRA
     CLHDFRSPAS NWSRLLYILD ASQQKSSDPV SPSPTSNNTS VSLRFVSRLV KHFASIRSAH
     RRDACVLVQL CFLPPVPFAA AGRKTRRSRR RRRWRRARSP KSTPPRLRRN TKVNV
//