ID A0A671VGQ2_SPAAU Unreviewed; 1087 AA.
AC A0A671VGQ2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSSAUP00010025660.1};
GN Name=LOC115596465 {ECO:0000313|Ensembl:ENSSAUP00010025660.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010025660.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010025660.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A671VGQ2; -.
DR Ensembl; ENSSAUT00010027117.1; ENSSAUP00010025660.1; ENSSAUG00010011063.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1023..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 750..807
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 121712 MW; D2C7A150D6CD08D8 CRC64;
MRMRGYEPLS PLSSGIQPPA PPLMHRLHQH LGTLVRAPLH LPTVRSRTPL RQGKNGRFYA
GDGAQVDVTV EEDAAVASWR RTRSARSAET WSGFRPEGGE DAAFSDQEEF QLTSSTFALA
GDTAHNQAMV HWSGQNSSVI LMLTKYYDFN SGRIFNLNFI YYLVMTQISC DIMLLTDPEV
ESSLLISLDE GASYQKHSLA FDILSLLFHP EQEDWILAYS HDQKLYVSVE FGRRWQLVHD
GVVPNRFYWS RLGLDKEQGM IHLEISVSDG RSQYITCKLQ NCSDGNKGKP FPGFIIPNSL
VVQDEYVFIQ VPIGGQSVHY VSYKRNSFYP MKLPKYTLPK DLQIISTDDN QVVAAIQDWH
QNDSYNLYMS ESRGLFFTLM LESVVSSGGP EGNIMIDLYE VAGIKGVFLS NKVVENQVKT
YITYNKGRDW RLLQAPTTDL QGNKVYCEQP YCSLHLHLHV SENPYTSGNI VSKESAPGII
IASGVVGPEL TSTNVSIFIT SDAGNSWREV FQEEYSVFFL NQGGSLVAIR HTPLPIRHIW
LSFDEGRNWD KYSFTSSPLY VDGVLGEPGE DTLIMTIFGH FSHRSEWQLV KIDFRSIFQH
RCTTDDYMTW QLHNEGEVCI MGMKRIYQKL KANVRCVKAR EQYISQMSDS CPCTEADFEC
DYGFERRIDG SCTPAFWFVP SATSRDCITG DSFLNTTGYR RALSNNCTEG AMLQFSPRRQ
KCPSQAPRGL QLFTSEGTLV ATVERNVTFL VFLEEGLSST TSITVDFGDG TAISYVNISS
IEDGVKHIYS KVGIYQVSAT ATNTLGSDRV ILYLHITCQL EQVQLSAPSV VVKNKAVNLT
TVLRPSNVGT VIFYWWFDNK TEPVVTLDGA TSFTFSKEGI HTVSVQASVG NTVLQDQMNV
AVYDYFRSHV LAFSSNLDEL NPGVPEWRED VGRVVKSSMV QVTGISEDQL LVTVLPGLPT
TAEIFIVPEK RSRHGDTDEK WAHLDQVASP QIILTVALNF SFHSVSFKAP LVDSSDSGHS
GTAVIMLVSV VLMGLAVFVI YKFKRYTVPK PEGDKLTSLD HVDVQLDSKG RGIHGPVYFL
SATFIPQ
//
