ID A0A671VGY4_SPAAU Unreviewed; 1270 AA.
AC A0A671VGY4;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSSAUP00010025409.1};
GN Name=LOC115596465 {ECO:0000313|Ensembl:ENSSAUP00010025409.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010025409.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010025409.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A671VGY4; -.
DR Ensembl; ENSSAUT00010026846.1; ENSSAUP00010025409.1; ENSSAUG00010011063.1.
DR GeneTree; ENSGT01030000234563; -.
DR InParanoid; A0A671VGY4; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025424030"
FT TRANSMEM 1145..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 861..918
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 69..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 141588 MW; 910AC9459C712BD7 CRC64;
METRLGHCLF LIFSEWIWLF TLTSILGGTK AEVRCIPSCQ LPPITAASAR ELSALDLVNF
GEDFVGFTER SPGAEPSAGG EERHSVAELT TSEESSRKVR GNDTSRLEKD GQQKLSQPKV
VSRSLSRAAA LSPDENSSDE GKNGRFYAGD GAQVDVTVEE DAAVASWRRT RSARSAETWS
GFRPEGGEDA AFSDQEEFQL TSSTFALAGD TAHNQAMVHW SGQNSSVILM LTKYYDFNSG
RVTESSLWRS TDYGTTYEKL NEKVGLKTIL SYLYVSPNNK RKIMLLTDPE VESSLLISLD
EGASYQKHSL AFDILSLLFH PEQEDWILAY SHDQKLYVSV EFGRRWQLVH DGVVPNRFYW
SRLGLDKEQG MIHLEISVSD GRSQYITCKL QNCSDGNKGK PFPGFIIPNS LVVQDEYVFI
QVPIGGQSVH YVSYKRNSFY PMKLPKYTLP KDLQIISTDD NQVVAAIQDW HQNDSYNLYM
SESRGLFFTL MLESVVSSGG PEGNIMIDLY EVAGIKGVFL SNKVVENQVK TYITYNKGRD
WRLLQAPTTD LQGNKVYCEQ PYCSLHLHLH VSENPYTSGN IVSKESAPGI IIASGVVGPE
LTSTNVSIFI TSDAGNSWRE VFQEEYSVFF LNQGGSLVAI RHTPLPIRHI WLSFDEGRNW
DKYSFTSSPL YVDGVLGEPG EDTLIMTIFG HFSHRSEWQL VKIDFRSIFQ HRCTTDDYMT
WQLHNEGEVC IMGMKRIYQK LKANVRCVKA REQYISQMSD SCPCTEADFE CDYGFERRID
GSCTPAFWFV PSATSRDCIT GDSFLNTTGY RRALSNNCTE GAMLQFSPRR QKCPSQAPRG
LQLFTSEGTL VATVERNVTF LVFLEEGLSS TTSITVDFGD GTAISYVNIS SIEDGVKHIY
SKVGIYQVSA TATNTLGSDR VILYLHITCQ LEQVQLSAPS VVVKNKAVNL TTVLRPSNVG
TVIFYWWFDN KTEPVVTLDG ATSFTFSKEG IHTVSVQASV GNTVLQDQMN VAVYDYFRSH
VLAFSSNLDE LNPGVPEWRE DVGRVVKSSM VQVTGISEDQ LLVTVLPGLP TTAEIFIVPE
KRSRHGDTDE KWAHLDQLSQ VLLSALNQDL IQFTLRPGVQ VNVYATRLSP APLVDSSDSG
HSGTAVIMLV SVVLMGLAVF VIYKFKRYSM LDVFLTTYEV RKNVGGFILQ NVRTHIVSNA
CDGRGIMLSL SPTCLCVCVC VCVCVCVCVC VLRKSQPHYL RASHLAGELP KLSASIQTPY
ISELWTSPTQ
//
