ID   A0A671VHM3_SPAAU        Unreviewed;      1196 AA.
AC   A0A671VHM3;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=VPS10 domain-containing receptor SorCS1-like {ECO:0000313|Ensembl:ENSSAUP00010025684.1};
GN   Name=LOC115596465 {ECO:0000313|Ensembl:ENSSAUP00010025684.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010025684.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010025684.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A671VHM3; -.
DR   Ensembl; ENSSAUT00010027141.1; ENSSAUP00010025684.1; ENSSAUG00010011063.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1196
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025548773"
FT   TRANSMEM        1107..1125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          828..885
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          69..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1196 AA;  133128 MW;  111877D4DF9DA904 CRC64;
     METRLGHCLF LIFSEWIWLF TLTSILGGTK AEVRCIPSCQ LPPITAASAR ELSALDLVNF
     GEDFVGFTER SPGAEPSAGG EERHSVAELT TSEESSRKVR GNDTSRLEKD GQQKLSQPKV
     VSRSLSRAAA LSPDENSSDE GKNGRFYAGD GAQVDVTVEE DAAVASWRRT RSARSAETWS
     GFRPEGGEDA AFSDQEEFQL TSSTFALAGD TAHNQAMVHW STDYGTTYEK LNEKVGLKTI
     LSYLYVSPNN KRKIMLLTDP EVESSLLISL DEGASYQKHS LAFDILSLLF HPEQEDWILA
     YSHDQKLYVS VEFGRRWQLV HDGVVPNRFY WSRLGLDKEQ ALVSCLPTGS QYITCKLQNC
     SDGNKGKPFP GFIIPNSLVV QDEYVFIQVP IGGQSVHYVS YKRNSFYPMK LPKYTLPKDL
     QIISTDDNQV VAAIQDWHQN DSYNLYMSES RGLFFTLMLE SVVSSGGPEG NIMIDLYEVA
     GIKGVFLSNK VVENQVKTYI TYNKGRDWRL LQAPTTDLQG NKVYCEQPYC SLHLHLHVSE
     NPYTSGNIVS KESAPGIIIA SGVVGPELTS TNVSIFITSD AGNSWREVFQ EEYSVFFLNQ
     GGSLVAIRHT PLPIRHIWLS FDEGRNWDKY SFTSSPLYVD GVLGEPGEDT LIMTIFGHFS
     HRSEWQLVKI DFRSIFQHRC TTDDYMTWQL HNEGEVCIMG MKRIYQKLKA NVRCVKAREQ
     YISQMSDSCP CTEADFECDY GFERRIDGSC TPAFWFVPSA TSRDCITGDS FLNTTGYRRA
     LSNNCTEGAM LQFSPRRQKC PSQAPRGLQL FTSEGTLVAT VERNVTFLVF LEEGLSSTTS
     ITVDFGDGTA ISYVNISSIE DGVKHIYSKV GIYQVSATAT NTLGSDRVIL YLHITCQLEQ
     VQLSAPSVVV KNKAVNLTTV LRPSNVGTVI FYWWFDNKTE PVVTLDGATS FTFSKEGIHT
     VSVQASVGNT VLQDQMNVAV YDYFRSHVLA FSSNLDELNP GVPEWREDVG RVVKSSMVQV
     TGISEDQLLV TVLPGLPTTA EIFIVPEKRS RHGDTDEKWL SQVLLSALNQ DLIQFTLRPG
     VQVNVYATRL SPAPLVDSSD SGHSGTAVIM LVSVVLMGLA VFVIYKFKRK IPGINTYTVE
     QTDKEQEVIP TVTSIAVPKP EGDKLTSLDH VDVQLDSKGR GIHGPVYFLS ATFIPQ
//