ID A0A671VND3_SPAAU Unreviewed; 936 AA.
AC A0A671VND3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSSAUP00010027930.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSSAUP00010027930.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010027930.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010027930.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A671VND3; -.
DR Ensembl; ENSSAUT00010029447.1; ENSSAUP00010027930.1; ENSSAUG00010011850.1.
DR GeneTree; ENSGT00940000158642; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 428..619
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 648..735
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 819..916
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 750..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 530..560
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 750..766
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 109062 MW; 84B69B06C15991F1 CRC64;
MGEIDGSYRV LQTPGTRLGA QFNAGISTLE PGQSLSGNMI SGSRSQGRGL HIRVQGLDDS
QEFFDIDPKA PAQTLLSEVF LRGNLMESDY FGLEFQNMQM NWVWLEPIKP VAKQVRRPSN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLMEGRLI CTENTGALLA SHLVQSEIGD
YDDVADRDFL RVNKLLPYQE KVQERIMELH RRHLGQTPAE SDFQILEIAR KLEMYGVRYH
PAADREGTKI NLAVSHMGLQ VFQGNTKINT FNWSKIRKLS FKRKRFLIKL YPEVHGPHQD
TLEFMMASRD QCKIFWKICV EYHSFFRLFD QPQPKSKAIL FTRGSSFRYS GRTQKQLVEY
VRENGAKRTP YQRCVFPYTV CTLFIRQTPC LPYQFLLSWR WRKDQVVVYI VYFKTHVPLF
SQRYPTDKAY FIAKEILTTE RTYLKDLEVI TVWFRSAVIK ENAMPEGLMT LLFSNIDPIY
EFHRGFLKEL DQRLALWWGR SNAHVKGDYQ RIGDVMLRNM CALKEFTSYL QKHDEVLTEL
EKATKRLKKL ETVYKEFELQ KVCYLPLNTF LLKPIQRLMH YKLILERLCK HYSPSHRDHD
DCKEALKEVA EIATQLQSSL IRLENFQKLT ELQRDLIGIE NLTAPGREFI REGCLYKLTK
KGLQQRMFFL FSDMLLYTSK GVTATNQFKV HGQLPLHGMI VEESENEWSV PHCFTIYSAQ
RTIVVAHKKI VFLKAFSLKC TVNPFPSKQL PVLPPPPLPP PPPSGSSDEV SLEQESEDDM
NSSRTSLDKQ THHRANTTMH VCWHRNTSVS MSDHSLAVEN QLSGYLLRKF KNSNGWQKLW
VVFTNFCLFF YKTHQDDFPL ASLPLLGYTV STPEESDSIH KEYVFKLQFK SHVYFFRAES
EYTFERWMEV IKSAASTAGR MSLLIPKGGP MEMNGN
//
