ID A0A671VXF2_SPAAU Unreviewed; 319 AA.
AC A0A671VXF2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Voltage-dependent calcium channel gamma-2 subunit {ECO:0000256|RuleBase:RU363085};
GN Name=CACNG2 {ECO:0000313|Ensembl:ENSSAUP00010031200.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010031200.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010031200.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC selective glutamate receptors (AMPARs). Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC slowing their rates of activation, deactivation and desensitization.
CC Does not show subunit-specific AMPA receptor regulation and regulates
CC all AMPAR subunits. Thought to stabilize the calcium channel in an
CC inactivated (closed) state. {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR AlphaFoldDB; A0A671VXF2; -.
DR Ensembl; ENSSAUT00010032879.1; ENSSAUP00010031200.1; ENSSAUG00010013327.1.
DR GeneTree; ENSGT01050000244893; -.
DR InParanoid; A0A671VXF2; -.
DR OMA; FPIMSVI; -.
DR OrthoDB; 2957055at2759; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR005422; VDCC_g2su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01602; VDCCGAMMA2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 179..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 35365 MW; 49D0A09B8946DCE7 CRC64;
MGVFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KIKSTNENET SKKNEEVMTH
SGLWRTCCLE GSFKGMCKQI DHFPEDADYE ADASEYFLRA VRASSIFPIL SVILLFMGGL
CIAASEFYKS RHNIILSSGI LFVSAGLSNI IGIIVYISAN AGDPSKSDSK KNSYSYGWSF
YFGALSFIMA EMVGVLAVHM FIDRHRELRV GARAADYLQG AAITRIPSYR YRYRRRSRSS
SRSTDPSHSR EASPVGLKAF GTLPSTELSM YTLPKGQTGT PTATYNSTER DHNFLQVHNC
ITKDLKDSGN TANRRTTPV
//
