ID   A0A671W370_SPAAU        Unreviewed;       440 AA.
AC   A0A671W370;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN   Name=hsdl2 {ECO:0000313|Ensembl:ENSSAUP00010031106.1};
OS   Sparus aurata (Gilthead sea bream).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Sparus.
OX   NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010031106.1, ECO:0000313|Proteomes:UP000472265};
RN   [1] {ECO:0000313|Ensembl:ENSSAUP00010031106.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000256|ARBA:ARBA00037788}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   AlphaFoldDB; A0A671W370; -.
DR   Ensembl; ENSSAUT00010032784.1; ENSSAUP00010031106.1; ENSSAUG00010013171.1.
DR   GeneTree; ENSGT00940000156729; -.
DR   InParanoid; A0A671W370; -.
DR   OMA; WWSSVAN; -.
DR   Proteomes; UP000472265; Unplaced.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd09762; HSDL2_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55718; SCP-like; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472265}.
FT   DOMAIN          344..432
FT                   /note="SCP2"
FT                   /evidence="ECO:0000259|Pfam:PF02036"
FT   REGION          309..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  47148 MW;  EA591676CD428F77 CRC64;
     LRVSQAPSFR SSSSCSACCE AIEQGTFTLA GLTLFVTGGS RGIGKAIALK AARDGANVII
     AAKTAVPHPK LPGTIYTAAE EVEAAGGKAL ACVVDIRDEQ QIEEAVQKAV DKFGGIDILV
     NNASAISLTG TLETPMKKVD LMLGINLRGT YLTSKLVIPH LLKSRSPHIL NLSPPLNLNP
     VWFKNHTAYT MAKYGMSMCV LGMAEEFRGQ IAVNALWPRT AIQTAAMDML GGDGIGKQCR
     TADIMADAAY AILSRPKDYT GHFVVDEDIL KEEGVQDFEQ YAVQPGHPLL PDFFLDDAPE
     TLVKKMEQHG ATPAFKPPSS SAAPPSSSGP IESTFDVIRA VINEDVVKTT QGVYQFDLSG
     EHGGMWFLDL KSGSGSAGQG EPPIKADVIM KLDSNDFTKM FAGKLKPTLA FMSGKLRIKG
     DMTLAIKLEK LMSRMNKAKL
//