ID A0A671WIJ1_SPAAU Unreviewed; 2198 AA.
AC A0A671WIJ1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Polycystic kidney disease 1b {ECO:0008006|Google:ProtNLM};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010036386.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010036386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR Ensembl; ENSSAUT00010038310.1; ENSSAUP00010036386.1; ENSSAUG00010015369.1.
DR GeneTree; ENSGT00940000164905; -.
DR InParanoid; A0A671WIJ1; -.
DR OMA; MAVTAYH; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR46730:SF4; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF00801; PKD; 2.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 2.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 2.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1239..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1449..1470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1490..1509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1755..1774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1840..1861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1882..1900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1932..1952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1972..1995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2031..2052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..68
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 97..147
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 154..671
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1284..1405
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 525..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2160..2179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2198 AA; 245087 MW; 8D0C7F3BDD4AE262 CRC64;
NTDVTFQAVT EVADPVEFLW HFGDSTSART TSRTTTTRYH KPGRYDVVAV MSSGRTSFTS
DAFPLVVQRA VKLNRLMHQA SVLQNQMATV SCRVNMGTNV SFLWSFGDGS SRLGQSTEQH
IFHSTGEFTV TVTVSNLVSS ASLSSHIFAV DRPCQPPPVK HMGPLKIQVR RYEVIRLGVT
YETEVDCDVS GGLRYTWTLS DSAGRDFPLP LVDTHRQSLV LPSYILRYDT YTARARVQVI
GSVVYSNYSV RVQVMPSPLV AFIQGGTNVF IRNRNTTVVA LDGQRSYDPD FPMSPVSFSW
SCKPVSSIAS SCFHRDVPTS FPVVTFPATF LKQNFDQFQF TLTIHSGERS ASSETFLTLT
ANVIGLSVYC PHCQGEHVNW DQSFSVSASC EGCDIDPSYI QYSWRLFSVN VSSKPLIEVP
FCYAVDLTAP STVIEGPATS PQTSVTTTHN SSESSIQKLD LNVTGSGTLS ENPLALDNSG
VLYLDHFGQS DVISKFTIDS SADWEFSSPV LESGDLDYDV PWMTAEEGDP GVSAGRPTGT
NLSPGDDSVS EPSLHEDEGS DLVDSRPSVV NQEPILLDLS RDLVDRGLFE SYTYTGISSS
LLDFRPFSLR PGSRYMLEVA AKSDDGLLGR TQLFLRTNPA PKGMTCQVQP AEGRELYTHF
SIFCASGKED LVYKYSIHAG DGPPRVLYQG RDFEYYFSLP SGDPSDDYKV TIYTEIRSSK
YGAATKPCPV TVRVRPISLL SSSESGLRNL SALVQLGNSV EVRNYISLLA GILNRLSLDA
EANTPAQRRT RSILIRTMCE LESREQASMV DIICILKHLL QATSQVTFAS ARQVTLHVQA
ISDGISESGA PVWYYLDEKT LHTLIVLLSN SLQAAVRYDD FTPEMSNSAD VKLPLESDSS
EENSGVYIRK GGSISKQVVQ LVGDTLQTAS DMMLVRENKY AREHRVNTGF IALYAEYQNQ
TSTVISSGSA AFYMPASLIQ HLFGRHNGEI ESRWHRPPCV LSMLTELTHS PYTWAHYPRR
LSGPVIDLSL YECSTRRKIS VRSLVQPINV EIQQPKSSVH EYVLQRCGVN YHSFNITQEH
LQQVIQLSVA FTPPLSKPFP ILLLFRMFER PTPSMHHLHR THRWESNTTQ FTLPSSYLSA
AGVAHLALLN ADLGKAPRHK HLSEEVSYTL TVESSLCLSW DNHQGAWTHH GCRTQPADMT
TAVSCSCHQL RPLTVVQHRI HSSHDATDLD PFLSVTSDLT VLGVLVLCVC LFIPGLVACK
KADVISKANR RVHYLSDNSQ CDPFLYAVTV HTGPCSAACM SAKVYIVLNG NDRVSLTKEL
QVPGCTLFRR NSQDTFIFSA ADSLGPVWGV HIWHDNSGPS PDWYLNYVEV SEVSRGHVKG
RAWLFVGRCW LAVVKGDGQV ERRLRVCTRG IGFAKMLRLK LSDYLADHHS WIPLLSCPGH
HSFTHTQRLS VNLLLLLGYA CVNAAIVSQM DDQLPFELGF TDVSAVSVRA GVLSVLAVLP
AAGVISFLFR LRDVELTRSG VQQVTGRKTE KGTDMLPASA TIVDNKNTDN EPVIQTDVIV
RKEAVEDNTG RALQSFLLIT EGNNVHQAPE GKESGILSER SSFYGAQKAF FHHILLRARQ
RARYLRLVRP PTAAELRVAR GKKRREALLH KTLRDLSVCG SMLLLMVCIN YGSSFSDHYH
LNKAVRRHRG RDNAFMSIQT HNEWWKWAQS SLLNSLYRNA SAAPEQSHIL IGEPILWKAE
VSSPFQGQVS NERRLCMYSA FACIVVLLSC RSHAASKLKL LHSGGWLGRR TVALKVQFTL
FSPAPNLFTG VTLLSEQSPT GVLLPSAKVQ SVRVYRAPAV WDYTVMVCQL IFLLLSVLQL
WDQMYTVGQQ GLMGYWRKPC NWLEVSLLTV TLVYYVYYIY HSVIILEVAE LLQRHNHRGH
VDVGVLATWE QYIRTLQGVT LFLLTLKCAT VLRVNRTLAA SATLLTRSLS SLFWPMVSAF
ILMVALCCEG NLVFIQSSGA FSSLPRFLQT LLCHRWSPRA VRGLHVPWSD FLYHGVLHLS
FTVVKVAVSS LIRRAKRSQS RQNICTAAEL VSYIRQRVSD FTGQRRKTYY LEEFESLVDE
LLFRLNALSN SLHHTLPYKA HRYREEDSSI ISPRQEPSNL DTQVKSGSLI KDWKEAVLDK
KDDERTTTNN SSLSKSQGTH TEVVVEVLVH EEPVSVAR
//
