ID A0A671WJP5_SPAAU Unreviewed; 1065 AA.
AC A0A671WJP5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSSAUP00010039101.1};
GN Name=LOC115573227 {ECO:0000313|Ensembl:ENSSAUP00010039101.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010039101.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010039101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A671WJP5; -.
DR Ensembl; ENSSAUT00010041228.1; ENSSAUP00010039101.1; ENSSAUG00010016492.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 3.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..306
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 406..461
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 502..653
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 667..785
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 783..921
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 973..1065
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 118827 MW; 42EFC267D14511EA CRC64;
MPINFTVVPV EDAEGDSNSA AEAGGNKPVS LGKLFGEKKD EDNLEESNKG EDNHRDSNSF
INSDDDGENY YEGKNMALFE EEMDSTPMVA SLLNKLANYT NLTQGVREHE EAENEDGVRR
VAVMVPQMGT FIGVYLPCMQ NILGVILFLR LTWIVGTAGI LGSFAIVSMC CICTLLTAIS
MSAIATNGVV PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGSMYILGT IEILLTYIVP
TAIVFNEDDG GAMPNNMRVY GTCCLLLMAL VVFVGVKYVN KLALVFLACV VLSIMATYAG
VIKTLIEPPE FNVCLLGNRS LRNDKFDTCA KLLKNDTGTT ELWRAFCNSS HRNATCDEYF
ELNNLTEMQA IPGLLSGVIK SEKESELPSS LFHLYPYVIN DIATYFTLLV GIYFPSVTGI
MAGSNRSGDL RDAQRSIPIG TIMAILTTSF IYISCVVLFG ASTALFDLFW PEDVFVLVFF
SFPPFNGVLF QTLSPSFCLL QVFGHGKTNG EPTWALLLTV GICEIGILFA SLDAVAPILS
MFFLMCYLFV NLACAVQTLL RTPNWRPRFK FYHWTLSFLG MSLCLSLMFV SSWYYALVAI
VIASCIYKYI EYKGAVKEWG DGIRGLSLNA ARYALIRLEE VPLHTKNWRP QLLVMCKLDA
DLAVKHPRLM SFSTQLKAGK GLTIVCSVLE GTYMTRRNDV KTGEQNLKAA MAAEKMKAFS
HVVVSSNLRD GFSLLIQSAG LGGMKHNAVL MAWPAGWKQA RDSSARRNFI ETVRETTEAQ
QALLVAKNID HFPGNQDRLK EGTIDVWWIV HDGGLLMLLP FLLSQHKVWR KCKMRIFTVA
QMDDNSIQMK KDLQMFLYHL RLDAEVEVVE MHDSDISAFT YEKTLVMEQR SQMLKQMQLS
RTEREREIQS ITDVSRGSIK RKKPSNEAVA CHLSFVQAQL IHDRNTASHS AMNDKAAAPD
RVHMTWTKDK LVHERNRQRE MGVKDMFNMK PNQSNVRRMH TAVKLNGVVV EKSQNSQLVL
LNMPGPPKNK KGDENYMEFL EVLMDGLDRV LLVRGGGREV ITIYS
//
