ID A0A671X4Z5_SPAAU Unreviewed; 1149 AA.
AC A0A671X4Z5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Solute carrier family 12 member 2-like {ECO:0000313|Ensembl:ENSSAUP00010043965.1};
GN Name=SLC12A2 {ECO:0000313|Ensembl:ENSSAUP00010043965.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010043965.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010043965.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A671X4Z5; -.
DR Ensembl; ENSSAUT00010046257.1; ENSSAUP00010043965.1; ENSSAUG00010007937.1.
DR GeneTree; ENSGT00940000155742; -.
DR InParanoid; A0A671X4Z5; -.
DR OMA; QDYVRCR; -.
DR Proteomes; UP000472265; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF105; SOLUTE CARRIER FAMILY 12 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..204
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 242..743
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 752..1149
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 70..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1149 AA; 125555 MW; 3B2773422EEFB716 CRC64;
LVLNAAALLP GHPRGFGAGV YFTVVVCLSV RSRLFGGVLS SIREDMSGQK PSLRSGDSAQ
SRFQVDVVTE GSPAAPAPVP APTQAPAPAS TDGSKPPEDS KGRFRVVGFM DPGALGSAMD
IGLPPDVSHE PDTARSDSVS LHSTGTGHTH ISDSHSNTYY MRTFGHNTID AVPNIDFYRQ
TAAPFGEKLS RPSLSELHDE LDKEPFEDGL ANGDEPSAAE EAAALAAKEG KGGTVKFGWV
KGVLVRCMLN IWGVMLFIRM SWIVGQAGIG LTIAIILMAS VVTTITGLST SAIATNGFVR
GGGAYYLISR SLGPEFGGSI GLIFAFANAV AVAMYVVGFA ETVVEMLNDV DALMTDELND
IRIVGTLTII LLLGISVAGM EWEAKAQIVL LVILLAAIVN YFIGSFMSTE SKEPKGFFGY
NTAIFIENLG PDFRDDETFF SVFAIFFPAA TGILAGANIS GDLTDPQSAI PKGTLLAILI
TGITYVFVAI SAGSCVVRDA TGDHNDTVSD TVNCTDAACT LGYDFSICKE GGCQFGLMND
FQVMSLVSGF GPLISAGIFS ATLSSALASL VSAPKVFQAL CKDNIYPGLG VFAKGYGKNN
EPLRGYVLTF CIGLAFILIA ELNIIAPIIS NFFLASYALI NFSVFHASLA NSPGWRPSFK
YYNMWVSLAG AILCCVVMFV INWWAALVTL LIVLALYIYV SYKKPDVNWG SSTQALIYNQ
ALTHCLNLTG VEDHVKNFRP QCLVLTGYPS SRPALLQLVH SFTKNVGLMV CGHIRTVTRR
PNFKELSQDH ARCQRWLNKK RIKAFYTTVF SDNLRHGTQF LLQAVGLGRL KPNTLVMGFK
NNWSDGDMRD VEIYINTIHD AFDLQFGVVI LRLQDALDVS HIQGQDELLS SHEKPPIGSK
EVVVSVILPK DSDFDSCPSK TTGNQSSPLI MRETKSPLSL TDQRLLETSQ QFKKKQGKGT
IDVWWLFDDG GLTLLIPFLL TNRSKWGDCR IRVFIGGKIN RIDHDRRAMA MLLSRFRIDF
SDIHVLGDIN TKPKKHNKLT FKELIEPYRL KEDDMEQEAA ERLKAQEPWR ITDNELELYK
AKTNRQIRLN ELLKEHSNAA KLIVMSMPLA RKGTVSSALY MCWLETLTKD VPPLLLVRGN
HQSVLTFYS
//
